Results 41 to 50 of about 86,092 (288)

MANP in Hypertension With Metabolic Syndrome

JACC: Basic to Translational Science
Summary: Hypertension and metabolic syndrome frequently coexist to increase the risk for adverse cardiometabolic outcomes. To date, no drug has been proven to be effective in treating hypertension with metabolic syndrome.
Xiao Ma, PhD, Paul M. McKie, MD, Seethalakshmi R. Iyer, MS, Christopher Scott, MS, Kent Bailey, PhD, Bradley K. Johnson, BS, Sherry L. Benike, RN, Horng Chen, MD, Wayne L. Miller, MD, Aderville Cabassi, MD, PhD, John C. Burnett, Jr., MD, Valentina Cannone, MD, PhD   +11 more
doaj   +1 more source

Natriuretic peptides and their usefulness in clinical practise

Journal of Education, Health and Sport, 2020
Natriuretic peptides are peptic hormones produced by atrial and ventricular myocytes, and by endothelium of blood vessels, that take part in homeostatic control of water and sodium levels, but also potassium transport, lipolysis in adipocytes and blood ...
Aleksandra Skałecka, Karol Krupa, Aleksandra Słabczyńska, Małgorzata Romaniuk, Konrad Suswał, Janusz Milanowski   +5 more
doaj   +1 more source

Porcine kidney xenotransplantation: From primate models to clinical reality

Animal Models and Experimental Medicine, EarlyView.
In the face of a critical shortage of human donor kidneys for end‐stage renal disease patients, porcine kidney xenotransplantation has emerged as a viable solution. This field has navigated major hurdles, including immune rejection, physiological incompatibilities, potential biomechanical differences and the risk of cross‐species infection. To overcome
Zihang Guo, Ling Zhang, Shoulong Deng, Chuan Qin   +3 more
wiley   +1 more source

Natriuretic peptides for the detection of paroxysmal atrial fibrillation in patients with cerebral ischemia--the Find-AF study.

PLoS ONE, 2012
Background and purposeDiagnosis of paroxysmal atrial fibrillation (AF) can be challenging, but it is highly relevant in patients presenting with sinus rhythm and acute cerebral ischemia.
Rolf Wachter, Rosine Lahno, Beatrice Haase, Mark Weber-Krüger, Joachim Seegers, Frank Edelmann, Janin Wohlfahrt, Götz Gelbrich, Anke Görlitz, Pawel Kermer, Dirk Vollmann, Gerd Hasenfuß, Klaus Gröschel, Raoul Stahrenberg   +13 more
doaj   +1 more source

Long‐Term Outcomes of Reduced‐Intensity Conditioning Hematopoietic Stem Cell Transplantation for Patients With Systemic Sclerosis With Impaired Cardiac Function

Arthritis &Rheumatology, EarlyView.
Objective High‐intensity conditioning autologous hematopoietic stem cell transplantation (AHSCT) is standard of care for patients with advanced systemic sclerosis (SSc). The role of reduced‐intensity conditioning (RIC) before AHSCT in this population remains unclear.
Yonatan Lean, Carrie Richardson, Anthony J. Esposito, Katy Bedjeti, George E. Georges   +4 more
wiley   +1 more source

Trypanosoma cruzi infection and endothelin-1 cooperatively activate pathogenic inflammatory pathways in cardiomyocytes. [PDF]

PLoS Neglected Tropical Diseases, 2013
Trypanosoma cruzi, the causative agent of Chagas' disease, induces multiple responses in the heart, a critical organ of infection and pathology in the host.
Ricardo S Corral, Néstor A Guerrero, Henar Cuervo, Núria Gironès, Manuel Fresno   +4 more
doaj   +1 more source

Natriuretic Peptides and Blood Pressure Homeostasis: Implications for MANP, a Novel Guanylyl Cyclase a Receptor Activator for Hypertension

Frontiers in Physiology, 2022
The heart serves as an endocrine organ producing the hormones atrial natriuretic peptide (ANP) and b-type natriuretic peptide (BNP) which via the guanylyl cyclase A (GC-A) receptor and the second messenger cGMP participate in blood pressure homeostasis ...
Valentina Cannone, Valentina Cannone, John C. Burnett, John C. Burnett   +3 more
doaj   +1 more source

Variability in ACT Response to Standard UFH Bolus During PCI: A Prospective Study on Determinants of Subtherapeutic Anticoagulation

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background Unfractionated heparin (UFH) remains the standard anticoagulant during percutaneous coronary intervention (PCI), with guidelines recommending a target activated clotting time (ACT) of ≥250 s. However, despite receiving a standardized bolus dose, many patients fail to achieve this target.
Manh Cuong Vu, Antonin Trimaille, Amandine Granier, Adrien Carmona, Anis Elidrissi, Marion Kibler, Laurence Jesel, Patrick Ohlmann, Laurent Sattler, Olivier Morel   +9 more
wiley   +1 more source

Acute effects of insulin on circulating natriuretic peptide levels in humans. [PDF]

PLoS ONE, 2018
The natriuretic peptide hormones play an important role in salt and blood pressure regulation. In observational studies, obesity and insulin resistance have been consistently associated with lower concentrations of natriuretic peptides.
Katherine N Bachmann, Serpil Muge Deger, Aseel Alsouqi, Shi Huang, Meng Xu, Jane F Ferguson, Yan Ru Su, Kevin D Niswender, T Alp Ikizler, Thomas J Wang   +9 more
doaj   +1 more source

C2238/αANP modulates apolipoprotein E through Egr-1/miR199a in vascular smooth muscle cells in vitro [PDF]

, 2015
Subjects carrying the T2238C ANP gene variant have a higher risk to suffer a stroke or myocardial infarction. The mechanisms through which T2238C/αANP exerts detrimental vascular effects need to be fully clarified.
Bianchi, Franca, Cotugno, Maria, DI CASTRO, SARA, FRATI, GIACOMO, MARCHITTI, Simona, RUBATTU, Speranza Donatella, SCARPINO, Stefania, SCIARRETTA, SEBASTIANO, Stanzione, Rosita, VOLPE, Massimo   +9 more
core   +1 more source