Results 31 to 40 of about 655,529 (373)
Frontiers in Physiology, 2021 The nuclear receptor subfamily 1, group D member 1 (Nr1d1), plays a role in the skeletal muscle’s oxidative capacity, mitochondrial biogenesis, atrophy genes, and muscle fiber size.
Rafael L. Rovina +8 more
doaj +1 more source
Mechanisms of IGF-1-Mediated Regulation of Skeletal Muscle Hypertrophy and Atrophy
Cells, 2020 Insulin-like growth factor-1 (IGF-1) is a key growth factor that regulates both anabolic and catabolic pathways in skeletal muscle. IGF-1 increases skeletal muscle protein synthesis via PI3K/Akt/mTOR and PI3K/Akt/GSK3β pathways. PI3K/Akt can also inhibit
Tadashi Yoshida, P. Delafontaine
semanticscholar +1 more source
Thbs1 induces lethal cardiac atrophy through PERK-ATF4 regulated autophagy
Nature Communications, 2021 The thrombospondin (Thbs) family of secreted matricellular proteins are stress- and injury-induced mediators of cellular attachment dynamics and extracellular matrix protein production.
D. Vanhoutte +8 more
semanticscholar +1 more source
Orphanet Journal of Rare Diseases, 2012 DEFINITION OF THE DISEASE: Dominant Optic Atrophy (DOA) is a neuro-ophthalmic condition characterized by a bilateral degeneration of the optic nerves, causing insidious visual loss, typically starting during the first decade of life. The disease affects primary the retinal ganglion cells (RGC) and their axons forming the optic nerve, which transfer the
Dominique Bonneau +11 more
openaire +7 more sources
Frontiers in Neurology, 2017 IntroductionMultiple sclerosis (MS) is characterised by the accumulation of permanent neurological disability secondary to irreversible tissue loss (neurodegeneration) in the brain and spinal cord.
Maria A. Rocca +4 more
doaj +1 more source
Efficacy and Mechanism Evaluation, 2020 Background: Neuroprotective drugs are needed to slow or prevent neurodegeneration and disability accrual in secondary progressive multiple sclerosis.
Floriana De Angelis +27 more
doaj +1 more source
Science Translational Medicine, 2020 Tau imaging with [18F]flortaucipir predicts the severity and topography of subsequent MRI cortical atrophy in patients with Alzheimer’s disease. Predictive PET Understanding the dynamic of the two major hallmark of Alzheimer’s disease (AD), tau protein ...
R. La Joie +21 more
semanticscholar +1 more source
Botulinum Toxin Induced Atrophy: An Uncharted Territory
Toxins, 2018 Botulinum neurotoxins (BoNTs) produce local chemo-denervation by cleaving soluble N-ethylmaleimide-sensitive factor activating protein receptor (SNARE) proteins.
Mehri Salari +2 more
doaj +1 more source
LGMD D2 TNPO3-Related: From Clinical Spectrum to Pathogenetic Mechanism
Frontiers in Neurology, 2022 Limb-girdle muscular dystrophies (LGMDs) are clinically and genetically heterogeneous diseases presenting with a wide clinical spectrum. Autosomal dominant LGMDs represent about 10–15% of LGMDs and include disorders due to defects of DNAJB6, transportin ...
Roberta Costa +8 more
doaj +1 more source
Анналы клинической и экспериментальной неврологии, 2017 Introduction. Cellular therapy of multiple sclerosis is currently considered to be one of the most promising treatment alternatives for this severe pathology of the nervous system. Materials and Methods.
Gennadiy N. Bisaga +5 more
doaj +1 more source