Results 31 to 40 of about 728,913 (287)

Withaferin A and Ovarian Cancer Antagonistically Regulate Skeletal Muscle Mass

Frontiers in Cell and Developmental Biology, 2021
Cachexia is a complex wasting syndrome that overwhelmingly affects the majority of late-stage cancer patients. Additionally, there are currently no efficacious therapeutic agents to treat the muscle atrophy induced by the cancer.
Alex R. Straughn, Natia Q. Kelm, Sham S. Kakar, Sham S. Kakar   +3 more
doaj   +1 more source

Tissue Iron in Friedreich Ataxia

Journal of Integrative Neuroscience
Heart, dentate nucleus, and dorsal root ganglia (DRG) are targets of tissue damage in Friedreich ataxia (FA). This report summarizes the histology and histopathology of iron in the main tissues affected by FA.
Arnulf H Koeppen
doaj   +1 more source

Distinct Features of Autoimmune Gastritis in Patients with Open-Type Chronic Gastritis in Japan

Biomedicines, 2020
In Asia, the incidences of Helicobacter pylori infection and gastric cancer are high, but their association with autoimmune gastritis (AIG) is unclear.
Mayo Tsuboi, Ryota Niikura, Yoku Hayakawa, Yoshihiro Hirata, Tetsuo Ushiku, Kazuhiko Koike   +5 more
doaj   +1 more source

Rates of lobar atrophy in asymptomatic MAPT mutation carriers. [PDF]

, 2019
IntroductionThe aim of this study was to investigate the rates of lobar atrophy in the asymptomatic microtubule-associated protein tau (MAPT) mutation carriers.MethodsMAPT mutation carriers (n = 14; 10 asymptomatic, 4 converters from ...
Boeve, Bradley F, Boxer, Adam L, Brushaber, Danielle, Chen, Qin, Dheel, Christina, Fields, Julie, Forsberg, Leah, Gavrilova, Ralitza, Gearhart, Debra, Graff-Radford, Jonathan, Graff-Radford, Neill R, Jack, Clifford R, Jones, David T, Kantarci, Kejal, Knopman, David S, Kremers, Walter K, Lapid, Maria, LEFFTDS Consortium, Lesnick, Timothy G, Rademakers, Rosa, Rosen, Howie, Senjem, Matthew, Syrjanen, Jeremy, Tosakulwong, Nirubol, Wszolek, Zbigniew K   +24 more
core   +2 more sources

Gyrus atrophy of the choroid and retina. A case presentation

Journal of Ophthalmology, 2023
Gyrus atrophy is a rare autosomal recessive hereditary disease secondary to a mutation of the OAT gene on chromosome 10 which results in a deficiency of the mitochondrial enzyme ornithine aminotransferase that causes a 20-fold increase in serum ...
Leopoldo Garduno Vieyra, Raul Rua Martinez, Natalia Rodriguez Mena, Gladys Villalobos Alonso   +3 more
doaj   +1 more source

HDAC4 preserves skeletal muscle structure following long-term denervation by mediating distinct cellular responses [PDF]

, 2018
BACKGROUND: Denervation triggers numerous molecular responses in skeletal muscle, including the activation of catabolic pathways and oxidative stress, leading to progressive muscle atrophy. Histone deacetylase 4 (HDAC4) mediates skeletal muscle response
Adamo, Sergio, Fulle, Stefania, Greco, Emanuela, Mancinelli, Rosa, Moresi, Viviana, Pigna, Eva, Renzini, Alessandra, Simonazzi, Elena   +7 more
core   +1 more source

Mesenchymal Stromal Cells and Their Secretome: New Therapeutic Perspectives for Skeletal Muscle Regeneration

Frontiers in Bioengineering and Biotechnology, 2021
Mesenchymal stromal cells (MSCs) are multipotent cells found in different tissues: bone marrow, peripheral blood, adipose tissues, skeletal muscle, perinatal tissues, and dental pulp.
Martina Sandonà, Lorena Di Pietro, Federica Esposito, Alessia Ventura, Antonietta Rosa Silini, Ornella Parolini, Ornella Parolini, Valentina Saccone, Valentina Saccone   +8 more
doaj   +1 more source

Determining the role of tumor-derived leukemia inhibitory factor in cancer cachexia using a genetic approach [PDF]

, 2018
Cachexia is a multifactorial metabolic wasting syndrome that affects a large percentage of cancer patients and results in the involuntary loss of skeletal muscle and adipose tissue.
Ganey, John
core  

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Impact of α-synuclein fibril structure on seeding activity in experimental models of Parkinson’s disease

npj Parkinson's Disease
The central pathogenesis of Parkinson’s disease involves the misfolding and aggregation of α-synuclein (α-syn). There is a widespread belief that α-syn can propagate in a prion-like manner, and α-syn preformed fibrils (PFFs) have been widely used to ...
Junichiro Ohira, Masanori Sawamura, Kenichi Kawano, Risa Sato, Tomoyuki Taguchi, Tomoyuki Ishimoto, Jun Ueda, Masashi Ikuno, Shu-ichi Matsuzawa, Katsumi Matsuzaki, Ryosuke Takahashi, Hodaka Yamakado   +11 more
doaj   +1 more source