Results 61 to 70 of about 425,260 (224)

The Inheritance of Peripapillary Atrophy [PDF]

Investigative Opthalmology & Visual Science, 2007
To estimate the relative importance of genes and environment in peripapillary atrophy type beta (beta-PPA) in a classic twin study.Female twin pairs (n = 506) aged 49 to 79 years were recruited from the St. Thomas' UK Adult Twin Registry. Peripapillary atrophy was identified from masked grading of stereoscopic optic disc photographs.
Paul R. Healey, Dongliang Ge, Harold Snieder, Harold Snieder, Paul Mitchell, Anne J. Lee, Tim D. Spector, Clare Gilbert, Christopher J Hammond   +8 more
openaire   +4 more sources

MRI Markers and Functional Performance in Patients With CIS and MS: A Cross-Sectional Study

Frontiers in Neurology, 2018
Introduction: Brain atrophy is a widely accepted marker of disease severity with association to clinical disability in multiple sclerosis (MS). It is unclear to which extent this association reflects common age effects on both atrophy and function ...
Ludwig Rasche, Michael Scheel, Michael Scheel, Karen Otte, Karen Otte, Patrik Althoff, Annemieke B. van Vuuren, Annemieke B. van Vuuren, Rene M. Gieß, Joseph Kuchling, Joseph Kuchling, Judith Bellmann-Strobl, Judith Bellmann-Strobl, Klemens Ruprecht, Friedemann Paul, Friedemann Paul, Friedemann Paul, Alexander U. Brandt, Alexander U. Brandt, Tanja Schmitz-Hübsch   +19 more
doaj   +1 more source

Case report of optic atrophy in Dentatorubropallidoluysian Atrophy (DRPLA) [PDF]

BMC Neurology, 2015
Dentatorubropallidoluysian atrophy (DRPLA) is a rare autosomal dominant neurodegenerative disease that is associated with numerous movement disorders. Ocular problems also occur with DRPLA with reports of corneal endothelial degeneration in some patients living with the disease.
Michael R. Silver, John C. Morgan, John C. Morgan, Shyamal H. Mehta, Kapil D. Sethi, Fenwick T. Nichols, Fenwick T. Nichols   +6 more
openaire   +3 more sources

Filamin C regulates skeletal muscle atrophy by stabilizing dishevelled-2 to inhibit autophagy and mitophagy

Molecular Therapy: Nucleic Acids, 2022
FilaminC (Flnc) is a member of the actin binding protein family, which is preferentially expressed in the cardiac and skeletal muscle tissues. Although it is known to interact with proteins associated with myofibrillar myopathy, its unique role in ...
Shunshun Han, Can Cui, Xiyu Zhao, Yao Zhang, Yun Zhang, Jing Zhao, Xiaoxu Shen, Haorong He, Jianping Wang, Menggen Ma, Diyan Li, Qing Zhu, Huadong Yin   +12 more
doaj  

Development of a computer-aided diagnostic system for Alzheimer's disease using magnetic resonance imaging [PDF]

arXiv, 2016
Alzheimer's disease (AD) is the most common type of dementia accompanied with brain atrophy. Structural measurements of brain atrophy in specific brain structures such as hippocampus using magnetic resonance imaging (MRI) have been reported to detect the development of dementia early in the course of the disease.
arxiv  

Assessing China’s Situation and Challenges [PDF]

Contemporary Chinese Political Economy and Strategic Relations: An International Journal, 2019
This article intends to assess China’s situation and challenges in the context of its deteriorating external and domestic environments. It focuses on the regime-maintenance initiatives of the Party regime and the prospects for political stability in ...
Joseph Yu-shek Cheng
doaj  

Differential Gray Matter Vulnerability in the 1 Year Following a Clinically Isolated Syndrome

Frontiers in Neurology, 2018
Background and purpose: Whether some gray matter (GM) regions are differentially vulnerable at the early stages of MS is still unknown. The objective of this study is to investigate whether deep and cortical GM are differentially vulnerable after a ...
Ismail Koubiyr, Ismail Koubiyr, Mathilde Deloire, Pierrick Coupé, Cécile Dulau, Pierre Besson, Amandine Moroso, Amandine Moroso, Vincent Planche, Vincent Planche, Vincent Planche, Thomas Tourdias, Thomas Tourdias, Thomas Tourdias, Bruno Brochet, Bruno Brochet, Bruno Brochet, Aurélie Ruet, Aurélie Ruet, Aurélie Ruet   +19 more
doaj   +1 more source

TGF-β Regulates Collagen Type I Expression in Myoblasts and Myotubes via Transient Ctgf and Fgf-2 Expression

Cells, 2020
Transforming Growth Factor β (TGF-β) is involved in fibrosis as well as the regulation of muscle mass, and contributes to the progressive pathology of muscle wasting disorders. However, little is known regarding the time-dependent signalling of
Michèle M. G. Hillege, Ricardo A. Galli Caro, Carla Offringa, Gerard M. J. de Wit, Richard T. Jaspers, Willem M. H. Hoogaars   +5 more
doaj   +1 more source

Modelling the Neuroanatomical Progression of Alzheimer's Disease and Posterior Cortical Atrophy [PDF]

arXiv, 2020
In order to find effective treatments for Alzheimer's disease (AD), we need to identify subjects at risk of AD as early as possible. To this end, recently developed disease progression models can be used to perform early diagnosis, as well as predict the subjects' disease stages and future evolution.
arxiv  

Riemannian tangent space mapping and elastic net regularization for cost-effective EEG markers of brain atrophy in Alzheimer's disease [PDF]

arXiv, 2017
The diagnosis of Alzheimer's disease (AD) in routine clinical practice is most commonly based on subjective clinical interpretations. Quantitative electroencephalography (QEEG) measures have been shown to reflect neurodegenerative processes in AD and might qualify as affordable and thereby widely available markers to facilitate the objectivization of ...
arxiv