Results 71 to 80 of about 655,529 (373)
PD-1 Alleviates Cisplatin-Induced Muscle Atrophy by Regulating Inflammation and Oxidative Stress
Antioxidants, 2022 Skeletal muscle atrophy is an important characteristic of cachexia, which can be induced by chemotherapy and significantly contributes to functional muscle impairment.
Xiaoguang Liu +5 more
doaj +1 more source
The Lancet Neurology, 2012 Posterior cortical atrophy (PCA) is a neurodegenerative syndrome that is characterised by progressive decline in visuospatial, visuoperceptual, literacy, and praxic skills. The progressive neurodegeneration affecting parietal, occipital, and occipitotemporal cortices that underlies PCA is attributable to Alzheimer's disease in most patients.
Jonathan M. Schott +6 more
openaire +5 more sources
Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, 1990 ABSTRACT:Weakness of distal muscles of one upper limb which progresses over 1 year and then appears to arrest (“monomelic amyotrophy”) has been reported mainly in Japan and India. We report 5 cases of a similar syndrome occurring in Canada. In our cases the wasting affected the forearm muscles of one upper limb (sparing brachioradialis and extensor ...
J, Oryema, P, Ashby, S, Spiegel
openaire +2 more sources
mTOR as a Key Regulator in Maintaining Skeletal Muscle Mass
Frontiers in Physiology, 2017 Maintenance of skeletal muscle mass is regulated by the balance between anabolic and catabolic processes. Mammalian target of rapamycin (mTOR) is an evolutionarily conserved serine/threonine kinase, and is known to play vital roles in protein synthesis ...
Mee-Sup Yoon
doaj +1 more source
Metabolites, 2021 Skeletal muscle contraction relies on both high-fidelity calcium (Ca2+) signals and robust capacity for adenosine triphosphate (ATP) generation. Ca2+ release units (CRUs) are highly organized junctions between the terminal cisternae of the sarcoplasmic ...
Antonio Michelucci +3 more
doaj +1 more source
Longitudinal tau accumulation and atrophy in aging and alzheimer disease
Annals of Neurology, 2019 To determine the rate of tau accumulation in healthy older adults (OA) and patients with Alzheimer disease (AD), as well as the relationship of tau accumulation to cortical atrophy.
Theresa M. Harrison +11 more
semanticscholar +1 more source
Glycine Protects Muscle Cells From Wasting in vitro via mTORC1 Signaling
Frontiers in Nutrition, 2019 Glycine supplementation can protect skeletal muscles of mice from cancer-induced wasting, but the mechanisms underlying this protection are not well-understood.
Marissa K. Caldow +5 more
doaj +1 more source
Preliminary Observations on Skeletal Muscle Adaptation and Plasticity in Homer 2-/- Mice
Metabolites, 2021 Homer represents a diversified family of scaffold and transduction proteins made up of several isoforms. Here, we present preliminary observations on skeletal muscle adaptation and plasticity in a transgenic model of Homer 2-/- mouse using a multifaceted
Paola Lorenzon +13 more
doaj +1 more source
Theranostics, 2020 Rationale: Peripheral nerve injury is common in clinic, which leads to severe atrophy and dysfunction of the denervated muscles, but the underlying mechanism is not fully understood. Recent studies advanced the causative role of mitochondrial dysfunction
Xiaofan Yang +7 more
semanticscholar +1 more source
The Inheritance of Peripapillary Atrophy [PDF]
Investigative Opthalmology & Visual Science, 2007 To estimate the relative importance of genes and environment in peripapillary atrophy type beta (beta-PPA) in a classic twin study.Female twin pairs (n = 506) aged 49 to 79 years were recruited from the St. Thomas' UK Adult Twin Registry. Peripapillary atrophy was identified from masked grading of stereoscopic optic disc photographs.
Paul R. Healey +8 more
openaire +4 more sources