Results 141 to 150 of about 157,892 (348)

Targeting acetylated high mobility group box 1 protein (HMGB1) and toll‐like receptor (TLR4) interaction to alleviate hypertension and neuroinflammation in fructose‐fed rats

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Our previous study reported that fructose intake increased systemic blood pressure and reduced nitric oxide (NO) in the nucleus tractus solitarius (NTS) due to oxidative stress and neuroinflammation. However, it remains unclear how reactive oxygen species (ROS) reduce NO and how this process impacts neuroinflammation in ...
Yu‐Te Lin   +6 more
wiley   +1 more source

The Synergistic Effects of Orthokeratology and Atropine in Slowing the Progression of Myopia

open access: yesJournal of Clinical Medicine, 2018
Atropine and orthokeratology (OK) are both effective in slowing the progression of myopia. In the current study, we studied the combined effects of atropine and OK lenses on slowing the progression of myopia. This retrospective study included 84 patients
L. Wan   +7 more
semanticscholar   +1 more source

Transcriptional and functional effects of mavacamten in multiple porcine and human models with hypertrophic cardiomyopathy

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Mavacamten (MAVA) is a novel small molecule inhibitor of cardiac myosin, mitigating cardiomyocyte hypercontractility in patients with hypertrophic obstructive cardiomyopathy (HOCM). Despite its recent approval for clinical use, the transcriptional and functional impacts of MAVA remain not well understood.
Elisa Kiselev   +36 more
wiley   +1 more source

Premyopia Management With Ophthalmic Referral Slows Myopic Shift After School Entry: A Population‐Based Longitudinal Study in Taiwan

open access: yesClinical &Experimental Ophthalmology, EarlyView.
ABSTRACT Background This study aimed to evaluate the impact of early ophthalmic referral for premyopic preschoolers on myopic spherical equivalent (SE) shift after school entry; and to identify risk factors for nonadherence to follow‐up care. Methods A population‐based longitudinal study followed 742 premyopic preschoolers (−0.5 D < SE ≤ +0.75 D) from ...
Yu‐Chieh Yang   +9 more
wiley   +1 more source

Antidote application: an educational system for treatment of common toxin overdose [PDF]

open access: yes, 2017
Poisonings account for almost 1% of emergency room visits each year. Time is a critical factor in dealing with a toxicologic emergency. Delay in dispensing the first antidote dose can lead to life-threatening sequelae.
Brusic, V.   +4 more
core  

Limbal cystotomy by fine needle aspiration of a translucent iris cyst in a horse

open access: yesEquine Veterinary Education, EarlyView.
Summary A 4‐year‐old Cremello crossbred mare was referred to the Equine Veterinary Teaching Hospital of Utrecht University for a translucent iris cyst from the dorsal pupillary margin corpora nigra in the right eye. Although noninvasive diode laser treatment is the preferred method of pigmented cyst ablation, two attempts did not result in disruption ...
A. L. Hendrikx   +5 more
wiley   +1 more source

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