Results 141 to 150 of about 114,786 (336)

Characterisation of the novel quinoline RCD405: Relaxant effects on cholinergic and histaminergic tone in human bronchi and small airways

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Increased contractility of human airway smooth muscle (hASM) is a hallmark of asthma and chronic obstructive pulmonary disease (COPD). Developing new classes of bronchodilators has proved to be challenging because of efficacy and safety concerns.
Paola Rogliani   +4 more
wiley   +1 more source

Polypharmacy in mice disrupts left ventricular function and structure and promotes proteome reorganisation in an age‐ and sex‐specific fashion

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and Purpose Most older people use polypharmacy (≥5 medications), particularly those with cardiovascular disease. The effects of polypharmacy on the cardiovascular system are not well described. We examined the effect of a chronic polypharmacy regimen on left ventricular (LV) function, structure and proteome in young and old mice of both ...
Trang Tran   +9 more
wiley   +1 more source

Glycopyrronium 320 μg/mL in children and adolescents with severe sialorrhoea and neurodisabilities: An open‐label study extension of the SALIVA trial

open access: yesDevelopmental Medicine &Child Neurology, EarlyView.
Plain language summary: https://onlinelibrary.wiley.com/doi/10.1111/dmcn.16268 Abstract Aims To test the long‐term efficacy, safety, and impact on quality of life (QoL) of an oral paediatric formulation of 320 μg/mL glycopyrronium in the 36‐week SALIVA (Sialanar plus orAl rehabiLitation against placebo plus oral rehabilitation for chIldren and ...
Pierre Fayoux   +7 more
wiley   +1 more source

Investigation of four diagnostic methods to identify infectious ulcerative keratitis in horses in Colorado, USA

open access: yesEquine Veterinary Education, EarlyView.
Summary Background Ulcerative keratitis in equine patients can result in keratomalacia and perforation. Prompt and accurate diagnostics are necessary for appropriate therapy and a favourable outcome. Objective To determine the diagnostic utility (specificity and speed) of four diagnostic methods for infectious ulcerative keratitis in the horse.
K. E. V. Jones   +5 more
wiley   +1 more source

Limbal cystotomy by fine needle aspiration of a translucent iris cyst in a horse

open access: yesEquine Veterinary Education, EarlyView.
Summary A 4‐year‐old Cremello crossbred mare was referred to the Equine Veterinary Teaching Hospital of Utrecht University for a translucent iris cyst from the dorsal pupillary margin corpora nigra in the right eye. Although noninvasive diode laser treatment is the preferred method of pigmented cyst ablation, two attempts did not result in disruption ...
A. L. Hendrikx   +5 more
wiley   +1 more source

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