Results 91 to 100 of about 2,041,165 (290)
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Reactive Attachment Disorder of Infancy or Early Childhood [PDF]
, 1994 Since its introduction into DSM-Ill, reactive attachment disorder has stood curiously apart from other diagnoses for two reasons: it remains the only diagnosis designed for infants, and it requires the presence of a specific etiology.
Richters, Dr. Margot Moser +1 more
core +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
Frontiers in Microbiology, 2017 Campylobacter jejuni is a major foodborne pathogen that causes severe gastroenteritis in humans characterized by fever, diarrhea, and abdominal cramps. In the human gut, Campylobacter adheres and invades the intestinal epithelium followed by cytolethal ...
Dan J. Donoghue +6 more
doaj +1 more source
, 2017 It is not uncommon for philosophers to name disinterestedness, or some like feature, as an essential characteristic of love. Such theorists claim that in genuine love, one’s concern for her beloved must be non-instrumental, non-egocentric, or even ...
Wonderly, Monique
core
Kinetics of node splitting in evolving complex networks [PDF]
, 2012 Copyright @ 2012 Elsevier B.V. All rights reserved. This is a preprint version of the published article which can be accessed at the link below.We introduce a collection of complex networks generated by a combination of preferential attachment and a ...
Albert +13 more
core +2 more sources
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
The Early Attachment Experiences are the Roots of Psychopathy [PDF]
Interpersona: An International Journal on Personal Relationships, 2009 This review proposes the ‘attachment and the deficient hemispheric integration hypothesis’ as explanation for psychopathy. The hypothesis states that since secure attachment to the parents is essential for the proper development of both the hemispheres ...
Neha Khetrapal
doaj
Love-led practice in children's residential care
Scottish Journal of Residential Child Care, 2023 The author describes a small-scale project, called Lovin' Care, designed to facilitate love-led practice in children's residential care in England.
Margaret Davies
doaj +1 more source