Results 91 to 100 of about 1,006,463 (366)

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

Molecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson, Emma L. Dorward, Kristyn Jurrius, Nathalie Nataren, Markus Tondl, Kay K. Myo Min, Michaelia P. Cockshell, Anahita Fouladzadeh, John Toubia, Mark DeNichilo, Delphine Merino, Claudine S. Bonder   +11 more
wiley   +1 more source

Conceptual Design and Parametric Optimization of a New Multileveled Horsetail Structure for Bicycle Helmets

Advanced Engineering Materials, EarlyView., 2023
This study aims to explore the feasibility of using a structure inspired by the features of horsetail and human spine as the potential helmet liner, targeting at mitigation of acceleration‐induced injuries. A parametric study is conducted to investigate the effect of individual geometrical variables in the design, indicating its capability to reduce ...
Bing Leng, Dong Ruan, Shanqing Xu, Kwong Ming Tse   +3 more
wiley   +1 more source

Statistical Models for Unsupervised Prepositional Phrase Attachment [PDF]

Proceedings of the 17th International Conference on Computational Linguistics (COLING-ACL '98), 1998
We present several unsupervised statistical models for the prepositional phrase attachment task that approach the accuracy of the best supervised methods for this task. Our unsupervised approach uses a heuristic based on attachment proximity and trains from raw text that is annotated with only part-of-speech tags and morphological base forms, as ...
arxiv  

Mediating Effects of Place Attachment and Satisfaction on the Relationship between Tourists’ Emotions and Intention to Recommend

, 2017
This study develops a model based on the developmental theory of place attachment. The model considers the influence of tourists’ emotions on place attachment and the mediating effects of satisfaction and place attachment on the relationship between ...
Sameer Hosany, G. Prayag, Robert van der Veen, S. Huang, S. Deesilatham   +4 more
semanticscholar   +1 more source

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

Flexural Behavior of Bidirectionally Graded Lattice

Advanced Engineering Materials, EarlyView., 2023
An experimental study of the bending behavior of bidirectional body‐centered cubic lattice beams is conducted in comparison to uniform and unidirectional counterparts of electron beam melted SS 316 L. Experimental results are used to develop and validate a finite element model which is subsequently used to conduct parametric studies to assess the ...
Chamini Rodrigo, Shanqing Xu, Yvonne Durandet, Darren Fraser, Dong Ruan   +4 more
wiley   +1 more source

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

Molecular Oncology, EarlyView.
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley   +1 more source

A Variational Beam Model for Failure of Cellular and Truss‐Based Architected Materials

Advanced Engineering Materials, EarlyView., 2023
Herein, a versatile and efficient beam modeling framework is developed to predict the nonlinear response and failure of cellular, truss‐based, and woven architected materials. It enables the exploration of their design space and the optimization of their mechanical behavior in the nonlinear regime. A variational formulation of a beam model is presented
Konstantinos Karapiperis, Kaoutar Radi, Zifan Wang, Dennis M. Kochmann   +3 more
wiley   +1 more source

Extending Binary Qualitative Direction Calculi with a Granular Distance Concept: Hidden Feature Attachment [PDF]

arXiv, 2010
In this paper we introduce a method for extending binary qualitative direction calculi with adjustable granularity like OPRAm or the star calculus with a granular distance concept. This method is similar to the concept of extending points with an internal reference direction to get oriented points which are the basic entities in the OPRAm calculus ...
arxiv  

Attachment in the Early Life Course: Meta‐Analytic Evidence for Its Role in Socioemotional Development

, 2017
After decades of research on early attachment relationships, questions remain concerning whether the evidence supports claims made by attachment theory, in particular, that variation in early attachment predicts children's developmental adaptation or ...
A. Groh, R. Fearon, Marinus H. van IJzendoorn, M. Bakermans‐Kranenburg, Glenn I. Roisman   +4 more
semanticscholar   +1 more source