Results 51 to 60 of about 93,133 (242)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Ruhiyah Attachment: Integrating Spirituality into Attachment Theory for Enhanced Child Development

Al-Athfal: Jurnal Pendidikan Anak
Purpose – This article aims to introduce a new perspective in attachment theory called ruhiyah attachment. Ruhiyah attachment emphasizes the role of caregivers as mediators to connect children spiritually with Allah SWT, proposing this spiritual ...
Sriyati Dwi Astuti, Nurjannah Nurjannah
doaj   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Relation of Attachment Styles with Positive and Negative Perfectionism

روانشناسی بالینی و شخصیت, 2007
The aim of this study was to examine the relationship between attachment styles and perfectionism. One hundred and seventy students (97 girls, 73 boys) were participated in this study.
M.A. Besharat, M. Joshanloo, M. Mirzamani   +2 more
doaj  

Does Long‐Term Lower Extremity Strength Training in Adults With Knee Osteoarthritis and Varus Alignment Reduce Knee Joint Loading During Gait?

Arthritis Care &Research, EarlyView.
Objective We examined whether 18 months of strength training in individuals with knee varus alignment and medial tibiofemoral osteoarthritis (OA) reduced knee joint loads during walking compared to an attention control group. Methods This study was a secondary analysis of a randomized clinical trial that compared the effects of strength training to a ...
Stephen P. Messier, Matthew N. Vigliotti, Paige E. Rice, Brian Pietrosimone, Shannon L. Mihalko, Edward H. Ip, Richard F. Loeser, David J. Hunter, Ali Guermazi, Ryan Hill, Santiago Saldana, Kim L. Bennell, Paul DeVita   +12 more
wiley   +1 more source

Relationship between attachment anxiety and attachment avoidance, mentalization ability, and various digital addictions: a cross-sectional study among university students

BMC Psychiatry
Background The increasing prevalence of digital media use has been accompanied by a rise in behavioral addictions, such as smartphone and social media addiction.
Lara Antonia Jasper, Henrik Bischoff, Christiane Eichenberg   +2 more
doaj   +1 more source

A Critical Analysis of the use of Attachment Theory in Cases of Domestic Violence

Critical Social Work, 2019
Social policies and social work practices are increasingly influenced by attachment theory.  Women who have been subjected to domestic violence by male partners are being assessed within this discourse, which takes little account of societal perspectives,
Fiona Buchanan
doaj   +1 more source

Cognitive Processes Unfold in a Social Context: A Review and Extension of Social Baseline Theory

Frontiers in Psychology, 2020
Psychologists often assume that social and cognitive processes operate independently, an assumption that prompts research into how social context influences cognitive processes. We propose that social and cognitive processes are not necessarily separate,
Elizabeth B. Gross, Sara E. Medina-DeVilliers   +1 more
doaj   +1 more source

Harnessing Fungal Biowelding for Constructing Mycelium‐Engineered Materials

Advanced Engineering Materials, EarlyView.
Mycelium‐bound composites (MBCs) offer low‐carbon alternatives for construction, yet interfacial bonding remains a critical challenge. This review examines fungal biowelding as a biocompatible adhesive, elucidating mycelium‐mediated interfacial mechanisms and their role in material assembly. Strategies to optimize biowelding are discussed, highlighting
Xue Brenda Bai, Xinrui Sarah Niu, Zhao Qin   +2 more
wiley   +1 more source