Results 61 to 70 of about 13,906,995 (244)

Structural Brain Correlates of Attention Dysfunction in Lewy Body Dementias and Alzheimer’s Disease

Frontiers in Aging Neuroscience, 2018
Lewy body dementia (LBD) and Alzheimer’s disease (AD) are common forms of dementia that have different clinical profiles but are both commonly associated with attentional deficits.
Ruth A. Cromarty, Julia Schumacher, Sara Graziadio, Peter Gallagher, Alison Killen, Michael J. Firbank, Andrew Blamire, Marcus Kaiser, Marcus Kaiser, Alan J. Thomas, John T. O’Brien, Luis R. Peraza, Luis R. Peraza, John-Paul Taylor   +13 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Neural Correlates of Cognitive Disengagement Syndrome Symptoms in Children: A Magnetoencephalography Study

Brain Sciences
Background/Objectives: Despite the growing recognition of cognitive disengagement syndrome (CDS), previously termed sluggish cognitive tempo, as a distinct dimension of psychopathology, the neural correlates of CDS remain largely unknown. We investigated
Xiaoqian Yu, Jing Xiang, Jeffery N. Epstein, Leanne Tamm, Josalyn A. Foster, Stephen P. Becker   +5 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Behavioral and Neuropsychological Correlates of Emotion Regulation via Attentional Deployment: An Expanded Replication

Europe's Journal of Psychology
Attentional deployment (AD) constitutes an emotion regulation (ER) strategy that shifts the attentional focus to modulate the emotional experience. There are very few experimental paradigms that can study AD.
Christian Salas, Nicolas Núñez, Luz María Pozo, Marko Bremer, Daniel Rojas-Líbano   +4 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Repeated measurement of the components of attention of older adults using the two versions of the Attention Network Test (ANT): stability, isolability, robustness, and reliability

Frontiers in Aging Neuroscience, 2011
Ishigami and Klein (2010) showed that scores of the three attention networks (alerting, orienting, and executive control) measured with the two versions of the Attention Network Test (ANT: Fan et al., 2002, Callejas et al., 2005) were robust over 10 ...
Yoko eIshigami, Raymond M Klein
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

PCS-Q-G. Parental Caregiving Style Questionnaire – German Version

Der PCS-Q-G dient der retrospektiven Erfassung des elterlichen Fürsorgeverhaltens. In Analogie zum 3-Kategorien-Modell von Bindung unterscheidet das Instrument zwischen den drei Stilen „warm/aufmerksam“, „ambivalent/inkonsistent“ und „kalt/abweisend ...
Rohmann, E., Neumann, E.
core   +1 more source