Results 81 to 90 of about 13,906,995 (244)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

CASQ. Coping Across Situations Questionnaire

Der CASQ erfasst das individuelle Bewältigungsverhalten von Jugendlichen in belastenden Situationen. 20 Bewältigungsstrategien in acht altersspezifischen Problembereichen werden den drei Subskalen "Aktive Bewältigung", "Internale Bewältigung" und ...
Seiffge-Krenke, I.
core   +1 more source

Staying Alert? Neural Correlates of the Association Between Grit and Attention Networks

Frontiers in Psychology, 2018
Recent research has demonstrated that heightened motivational levels promote enhanced attention capabilities. However, the relation between attentional systems and the trait-based ability to sustain a motivational state long-term is less understood. Grit
Vrinda Kalia, Robin Thomas, Kira Osowski, Anthony Drew   +3 more
doaj   +1 more source

Selective Attentional Networks Deficits in Parents of Children With Autism Spectrum Disorder: Evidence From Attention Network Test. [PDF]

Psychiatry Investig, 2023
Qin T, Wang Z, Li X, Zhang S.
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

A Hierachical Infrastrucutre for SOC Test Management [PDF]

, 2003
HD2BIST - a complete hierarchical framework for BIST scheduling, data-patterns delivery, and diagnosis of complex systems - maximizes and simplifies the reuse of built-in test architectures.
Zorian Y., Zorian, Y., Benso, Alfredo, Prinetto, Paolo Ernesto, Di Carlo, Stefano   +4 more
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Association Between the Attention Network Test, Neuropsychological Measures, and Disability in Post-Acute Traumatic Brain Injury. [PDF]

Neurotrauma Rep, 2023
Jaywant A, Blunt E, Jamison K, Kim N, RoyChoudhury A, Schiff ND, Kuceyeski A, Dams-O'Connor K, Shah S.   +8 more
europepmc   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Test exploration and validation using transaction level models [PDF]

, 2009
The complexity of the test infrastructure and test strategies in systems-on-chip approaches the complexity of the functional design space. This paper presents test design space exploration and validation of test strategies and schedules using transaction
M.E. Imhof, Wunderlich, H. J, M. Radetzki, Kochte, M.A, C.G. Zoellin, Khaligh, R. S, Zollen, C.G, H.-J. Wunderlich, R.S. Khaligh, Di Carlo, Stefano, Kochte, M. A, M.A. Kochte, P. Prinetto, Khaligh, R.S, Imhof, M. E, Zollen, C. G, Radetzki, M., Imhof, M.E, Wunderlich, H.-J, Prinetto, Paolo Ernesto, S. Di Carlo   +20 more
core   +1 more source