Results 51 to 60 of about 126,420 (251)

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Designing Stress-Relieving Small Inner-City Park Environments for Teenagers

Land
All over the world, teenagers suffer from stress-related mental illness, and research shows that being in natural environments can bring about recovery.
Aida Nosrati, Mahdieh Pazhouhanfar, Chongxian Chen, Patrik Grahn   +3 more
doaj   +1 more source

Virtual Reality Greenspaces: Does Level of Immersion Affect Directed Attention Restoration in VR Environments?

J, 2022
Research on attention restoration theory has provided consistent results over the years, and exposure to nature has been found to significantly improve and restore directed attention fatigue. However, rapid urbanisation has made it increasingly difficult
Denise Dillon, Jiaying Cai
doaj   +1 more source

Art Immersion: Evidence for Attention Restoration in Museums

Consciousness and Cognition
Navigating crowded urban environments can significantly deplete attentional resources over time, making individuals less attentive and more prone to distractions. While previous research suggests that natural settings can help replenish attentional resources depleted by urban life, little is known about whether similar benefits may arise from tranquil ...
Nicola Vasta, Francesco N. Biondi
openaire   +4 more sources

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Effects of Soundscape on the Environmental Restoration in Urban Natural Environments

Noise and Health, 2017
Context: According to the attention restoration theory, directed attention is a limited physiological resource and is susceptible to fatigue by overuse. Natural environments are a healthy resource, which allows and promotes the restoration of individuals
Yuan Zhang, Jian Kang, Joe Kang
doaj   +1 more source

Underwater Image Restoration and Enhancement via Residual Two-Fold Attention Networks

International Journal of Computational Intelligence Systems, 2020
Underwater images or videos are common but essential information carrier for observation, fishery industry and intelligent analysis system in underwater vehicles.
Bo Fu, Liyan Wang, Ruizi Wang, Shilin Fu, Fangfei Liu, Xin Liu   +5 more
doaj   +1 more source