Results 61 to 70 of about 126,420 (251)

Restoring Attention Networks.

The Yale journal of biology and medicine, 2019
The attention networks of the human brain have been under intensive study for more than twenty years and deficits of attention accompany many neurological and psychiatric conditions. There is more dispute about the centrality of attention deficits to these conditions.
Michael I, Posner, Mary K, Rothbart, Habibollah, Ghassemzadeh   +2 more
openaire   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Can Nature Walks With Psychological Tasks Improve Mood, Self-Reported Restoration, and Sustained Attention? Results From Two Experimental Field Studies

Frontiers in Psychology, 2018
The evidence for restorative effects of contact with nature is vast. Drawing from two well-known theories in Environmental Psychology, Stress reduction theory and Attention restoration theory, restoration can be seen as a sequential, interactive process ...
Tytti Pasanen, Katherine Johnson, Kate Lee, Kalevi Korpela   +3 more
doaj   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

The more the merrier? Perceived forest biodiversity promotes short‐term mental health and well‐being—A multicentre study

People and Nature
Forests can foster mental health and well‐being. Yet, the contribution of forest biodiversity remains unclear, and experimental research is needed to unravel pathways of biodiversity–health linkages.
Kevin Rozario, Rachel Rui Ying Oh, Melissa Marselle, Erich Schröger, Loïc Gillerot, Quentin Ponette, Douglas Godbold, Daniela Haluza, Katriina Kilpi, Dagmar Müller, Urte Roeber, Kris Verheyen, Bart Muys, Sandra Müller, Taylor Shaw, Aletta Bonn   +15 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

HAT: Hybrid Attention Transformer for Image Restoration

IEEE Transactions on Pattern Analysis and Machine Intelligence
Extended version of HAT.
Xiangyu Chen 0006, Xintao Wang 0002, Wenlong Zhang, Xiangtao Kong, Yu Qiao 0001, Jiantao Zhou 0001, Chao Dong 0005   +6 more
openaire   +3 more sources

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Enhancing Cognitive Performance and Physiological Benefit in Workspaces Through Patterns of Biophilic Design: A Restorative Approach

Buildings
Contact with nature is believed to enhance mental health through the process of human psychological restoration. However, prolonged indoor living limits individuals’ exposure to nature, potentially hindering the timely alleviation of stress and fatigue ...
Ping Zhang, Zhengqi Yu, Guoying Hou, Ping Shu, Yunque Bo, Yankun Shi, Rui Nie   +6 more
doaj   +1 more source