Results 91 to 100 of about 8,570,593 (242)
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
A frequency attention-embedded network for polyp segmentation
Scientific ReportsGastrointestinal polyps are observed and treated under endoscopy, so there presents significant challenges to advance endoscopy imaging segmentation of polyps.
Rui Tang +10 more
doaj +1 more source
U-net weights for brain segmentation
, 2018 U-net weights for U ...
Brian Avants (418551) +1 more
core +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
PEAK-U-Net: A Progressive Edge-Aware Attention KAN U-Net With Sliding Window for Crack Segmentation
IEEE AccessCrack detection and quantification in concrete structures remains a critical challenge in structural health monitoring. Traditional manual inspection methods are time-consuming and prone to human error, while existing deep learning approaches struggle ...
Priyo Suprobo +3 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
AttResDU-Net: Medical Image Segmentation Using Attention-based Residual Double U-Net
, 2023 Manually inspecting polyps from a colonoscopy for colorectal cancer or performing a biopsy on skin lesions for skin cancer are time-consuming, laborious, and complex procedures. Automatic medical image segmentation aims to expedite this diagnosis process.
Hasan, Md. Bakhtiar +4 more
core
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Residual wave vision U-Net for flood mapping using dual polarization Sentinel-1 SAR imagery
International Journal of Applied Earth Observations and GeoinformationThe increasing severity, duration, and frequency of destructive floods can be attributed to shifts in climate, infrastructure, land use, and population demographics.
Ali Jamali +5 more
doaj +1 more source