Results 71 to 80 of about 8,570,593 (242)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
CBAM U-Net Model-Based Precipitation Estimation for Chengdu X-band Phased Array Radar [PDF]
Gaoyuan qixiangThe frequent occurrence of heavy precipitation events poses severe challenges to urban disaster prevention and mitigation. High-resolution quantitative precipitation estimation （QPE） products are of great importance for monitoring intense rainfall ...
Cong ZHOU, Chenghong ZHANG, Yuanchang DONG, Tao ZHANG
doaj +1 more source
Acoustic Impedance Inversion from Seismic Imaging Profiles Using Self Attention U-Net
, 2023 Seismic impedance inversion is a vital way of geological interpretation and reservoir investigation from a geophysical perspective. However, it is inevitably an ill-posed problem due to the noise or the band-limited characteristic of seismic data ...
Liurong Tao, Haoran Ren, Zhiwei Gu
core +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
InformationIn practical applications, the clarity of analog dial images is often compromised due to factors such as lighting conditions, leading to low precision and poor segmentation of dial scales and pointers.
Wan Zou +6 more
doaj +1 more source
, 2023 This study proposes a bilateral attention U-Net with a dissimilarity attention gate (DAG) for change detection on remote sensing imageries. The proposed network is designed with a bilateral dissimilarity encoding for the DAG calculation to handle ...
Donggyu Sim +4 more
core +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source