Results 101 to 110 of about 2,790,656 (286)
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
, 2003 Aims: The effects of university students’ habitual drinking practices and experimental alcohol cue exposure on their attentional bias for alcohol-related stimuli were assessed.Methods: Participants were exposed in vivo to either an alcoholic or non ...
Rowlands, Lisa J. +2 more
core +1 more source
Modulating attentional load affects numerosity estimation: evidence against a pre-attentive subitizing mechanism [PDF]
, 2008 Traditionally, the visual enumeration of a small number of items (1 to about 4), referred to as subitizing, has been thought of as a parallel and pre-attentive process and functionally different from the serial attentive enumeration of larger ...
Petra Vetter +11 more
core +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Frontiers in PsychologyIntroductionThe Attention Network Test (ANT) is a widely used paradigm for assessing the efficiency of attentional subsystems. Although most ANT implementations rely on visual cues and stimuli, extending the ANT to the auditory domain is important for ...
Tianfang Han, Arianna N. LaCroix
doaj +1 more source
FEBS Open Bio, EarlyView.TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose +9 more
wiley +1 more source
Attentional Networks and Biological Motion [PDF]
Psihologija, 2010 Our ability to see meaningful actions when presented with pointlight traces of human movement is commonly referred to as the perception of biological motion.
Chandramouli Chandrasekaran +3 more
doaj
Frontiers in Aging Neuroscience, 2016 The present study compared young and older adults on behavioral and neural correlates of three attentional networks (alerting, orienting, and executive control).
David A S Kaufman +4 more
doaj +1 more source