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Live Attenuated Varicella Vaccine

The Journal of Pediatrics, 1984
Live attenuated varicella vaccine will in all probability soon be licensed in the United States for immunization of healthy children and adults and certain immunocompromised children. This vaccine can be expected to protect susceptibles from varicella (or to modify it) in those subsequently exposed to the wild virus.
openaire   +6 more sources

Roadblocks to translational challenges on viral pathogenesis. [PDF]

, 2013
Distinct roadblocks prevent translating basic findings in viral pathogenesis into therapies and implementing potential solutions in the clinic. An ongoing partnership between the Volkswagen Foundation and Nature Medicine resulted in an interactive ...
Deeks, Steven, Drosten, Christian, Picker, Louis, Subbarao, Kanta, Suzich, Joann   +4 more
core   +1 more source

Recent progress on gene-deleted live-attenuated African swine fever virus vaccines

npj Vaccines
African Swine Fever (ASF) is a highly lethal viral disease in swine, with mortality rates approaching 100%. The disease has spread to many swine-producing countries, leading to significant economic losses and adversely impacting global food security ...
Hiep L. X. Vu, D. S. McVey
semanticscholar   +1 more source

One-way trip: Influenza virus' adaptation to gallinaceous poultry may limit its pandemic potential [PDF]

, 2014
We hypothesise that some influenza virus adaptations to poultry may explain why the barrier for human-to-human transmission is not easily overcome once the virus has crossed from wild birds to chickens.
Alexander, Baigent, Banks, Banks, Belser, Blumenkrantz, Bosch, Brass, Bullough, Butt, Castrucci, Cauldwell, Chan, Chen, Chen, Cheng, Chutinimitkul, Cohen, Connor, Costa, Cotter, Cowling, Cox, De Jong, Dorigatti, DuBois, Elderfield, England, Everitt, Gabbard, Galloway, Gambaryan, Gambaryan, Gao, Garten, Handel, Harvey, Hatta, Hay, Herfst, Hoffmann, Imai, Jia, Karron, Keleta, Killingley, Koerner, Koopmans, Krenn, Kuchipudi, Li, Li, Lin, Lin, Linster, Luke, Maines, Matrosovich, Matrosovich, Matrosovich, Matrosovich, Matsuoka, Munier, Neumann, O'Donnell, Pappas, Peiris, Perdue, Reed, Roberts, Robinson, Roche, Rogers, Rott, Russell, Russell, Schrauwen, Shelton, Shi, Skehel, Smeenk, Sorrell, Sorrell, Steinhauer, Stevens, Suguitan, Sun, Tellier, Tharakaraman, Thoennes, Tumpey, Vines, Wan, Wang, Washington, Webster, Wei, Xiong, Yen, Zhang, Zhou, Zhou   +101 more
core   +2 more sources

Future research to underpin successful peste des petits ruminants virus (PPRV) eradication [PDF]

, 2017
Peste des petits ruminants virus (PPRV) is a significant pathogen of small ruminants and is prevalent in much of Africa, the Near and Middle East and Asia.
Bouna Diop, Brian J. Willett, Dalan Bailey, Diallo, Diallo, Felix Njeumi, Michael D. Baron, Munir, Robinson, Roeder, Zahur   +10 more
core   +1 more source

The Effects of Pre-Existing Antibodies on Live-Attenuated Viral Vaccines

Viruses, 2020
Live-attenuated vaccines (LAVs) have achieved remarkable successes in controlling virus spread, as well as for other applications such as cancer immunotherapy.
Darren Z L Mok, Kuan Rong Chan
semanticscholar   +1 more source

Live attenuated intranasal influenza vaccine [PDF]

Human Vaccines & Immunotherapeutics, 2012
Annual vaccination is the most effective means of preventing and controlling influenza epidemics, and the traditional trivalent inactivated vaccine (TIV) is by far the most widely used. Unfortunately, it has a number of limitations, the most important of which is its poor immunogenicity in younger children and the elderly, the populations at greatest ...
S. Esposito, V. Montinaro, E. Groppali, R. Tenconi, M. Semino, N. Principi   +5 more
openaire   +5 more sources

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

The safety of live-attenuated vaccines in patients using IL-1 or IL-6 blockade: an international survey

Pediatric Rheumatology Online Journal, 2018
BackgroundWithholding live-attenuated vaccines in patients using interleukin (IL)-1 or IL-6 blocking agents is recommended by guidelines for both pediatric and adult rheumatic diseases, since there is a risk of infection in an immune suppressed host ...
Jerold Jeyaratnam, N. T. ter Haar, H. Lachmann, O. Kasapcopur, A. Ombrello, D. Rigante, F. Dedeoğlu, Ezgi H. Baris, S. Vastert, N. Wulffraat, J. Frenkel   +10 more
semanticscholar   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source