Results 61 to 70 of about 1,089,157 (267)
The 3-Dimensional Distribution of Dust in NGC 891
, 2011 We produce three-dimensional Monte-Carlo radiative transfer models of the edge-on spiral galaxy NGC 891, a fast-rotating galaxy thought to be an analogue to the Milky Way. The models contain realistic spiral arms and a fractal distribution of clumpy dust.
Bershady, Matthew A. +2 more
core +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Road Traffic Noise Attenuation by Vegetation Belts at Some Sites in the Tarai Region of India
Archives of Acoustics, 2013 Noise measurements have been carried out at eleven different sites located in three prominent cities of the Tarai region of India to evaluate the effectiveness of vegetation belts in reducing traffic noise along the roadsides. Attenuation per doubling of
Vikrant TYAGI, Krishan KUMAR, V. JAIN
doaj
Simple Attenauation Models of Metallic Cables Suitable for G.fast Frequencies
Advances in Electrical and Electronic Engineering, 2015 Recently, a new xDSL successor called G.fast, which can occupy frequencies up to 106 or 212~MHz, has been introduced in ITU-T G.9700 series of recommendations.
Pavel Lafata
doaj +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Modelling of Attenuation and Crosstalk of Cascaded Transmission Lines
Advances in Electrical and Electronic Engineering, 2011 This paper deals with the measurements and modelling of attenuation and near-end (NEXT) and far-end (FEXT) crosstalk for cascaded metallic transmission lines.
Pavel Lafata
doaj +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Ground-Borne Vibration Due to Construction Works with Respect to Brownfield Areas
Applied Sciences, 2019 Ground-borne vibration caused by mechanized construction works is the most common problem in built-up areas in general. In post-industrial cities, there are many building facilities in the category of brownfields.
Martin Stolarik +2 more
doaj +1 more source