Results 41 to 50 of about 21,797 (258)

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

A Fast Lithium-Ion Battery Impedance and SOC Estimation Method Based on Two-Stage PI Observer

open access: yesWorld Electric Vehicle Journal, 2021
Due to the complex changes in battery state, the accurate and fast estimation of battery state of charge (SOC) is still a great challenge. Here, a fast estimation method of battery impedance and SOC based on a multi-level PI observer is proposed.
Tao Chen   +3 more
doaj   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

open access: yesFEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas   +6 more
wiley   +1 more source

Integrated Attenuation Compensation and Q-Constrained Inversion for High-Resolution Reservoir Characterization in the Ordos Basin

open access: yesApplied Sciences
Quantitative seismic characterization of transitional shale gas resources in the Da Ning–Ji Xian area, Ordos Basin, is severely hampered by complex coal-measure stratigraphy and rapid lithological variations.
Yugang Yang   +5 more
doaj   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

open access: yesFEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks   +4 more
wiley   +1 more source

Nonlinear dual reconstruction of SPECT activity and attenuation images.

open access: yesPLoS ONE, 2014
In single photon emission computed tomography (SPECT), accurate attenuation maps are needed to perform essential attenuation compensation for high quality radioactivity estimation.
Huafeng Liu   +4 more
doaj   +1 more source

Underwater image enhancement based on red channel weighted compensation and gamma correction model

open access: yesOpto-Electronic Advances, 2018
Due to the special characteristics of light in water, the information of the red channel is seriously attenuated in collected image. This causes other colors to dominate the image.
Xiang Wending   +4 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

open access: yesAging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Multidimensional Profiling of MRI‐Negative Temporal Lobe Epilepsy Uncovers Distinct Phenotypes

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Although hippocampal sclerosis (TLE‐HS) represents the most frequent cause of temporal lobe epilepsy (TLE), up to 30% of patients show no lesion on visual MRI inspection (TLE‐MRIneg). These cases pose diagnostic and therapeutic challenges and are underrepresented in surgical series.
Alice Ballerini   +28 more
wiley   +1 more source

StigDiff: Stigmergy Diffusion for Signal Compensation in Multi-Agent Localization

open access: yesIEEE Open Journal of Intelligent Transportation Systems
Multi-agent localization faces the problem of signal loss or attenuation. To address the signal compensation problem, we propose a novel diffusion model for multi-agent signal compensation, named StigDiff.
Yan Zhang, Rong Xie
doaj   +1 more source

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