Results 41 to 50 of about 17,377 (218)

ATTR Gene Variants in HCM

JACC: Case Reports
Hypertrophic cardiomyopathy is the most common inherited cardiomyopathy, with a prevalence of 1:200 to 1:500. Cardiac amyloidosis, another cardiomyopathy caused by myocardial deposition of abnormally folded TTR protein, can be acquired or hereditary. The presence of pathogenic TTR gene variants in patients with phenotypic HCM is an underrecognized and ...
Kanelidis, Anthony J., Slivnick, Jeremy A., Campagna, Rachel, Smith, Bryan, Kalantari, Sara, Sarswat, Nitasha, Kim, Gene   +6 more
openaire   +4 more sources

Baseline characteristics of patients with ATTR cardiac amyloidosis.

, 2021
Data are presented as percentages, as appropriate. Abbreviations: ATTR, transthyretin amyloidosis. (DOCX)
Zaza Iakobishvili (505022), Noa Rhurman-Shahar (11250356), Ashraf Hamdan (3579284), Osnat Itzhaki Ben Zadok (6235943), Mordehay Vaturi (11250350), Iuliana Vaxman (11250353), Ran Kornowski (540888)   +6 more
core   +1 more source

Cryo-EM structure of an ATTRwt amyloid fibril from systemic non-hereditary transthyretin amyloidosis

Nature Communications, 2022
This manuscript reports the structure of a pathologically relevant wild type ATTR amyloid fibril from systemic non-hereditary transthyretin amyloidosis.
Maximilian Steinebrei, Juliane Gottwald, Julian Baur, Christoph Röcken, Ute Hegenbart, Stefan Schönland, Matthias Schmidt   +6 more
doaj   +1 more source

Structural basis for transthyretin amyloid formation in vitreous body of the eye

Nature Communications, 2021
Systemic ATTR amyloidosis causes the abnormal accumulation of ATTR fibrils formed from the human plasma protein transthyretin (TTR) in multiple organs including the eye.
Irina Iakovleva, Michael Hall, Melanie Oelker, Linda Sandblad, Intissar Anan, A. Elisabeth Sauer-Eriksson   +5 more
doaj   +1 more source

Progression and prognostic significance of electrocardiographic findings in patients with cardiac amyloidosis

ESC Heart Failure, Volume 12, Issue 2, Page 809-818, April 2025.
Abstract Aims This study aimed to evaluate the change of the main electrocardiographic (ECG) characteristics and their prognostic role across the main subtypes of cardiac amyloidosis [light‐chain amyloidosis (AL) and hereditary (ATTRv) and wild‐type transthyretin amyloidosis (ATTRwt)].
Alessia Argirò, Mattia Zampieri, Carlotta Mazzoni, Carlo Fumagalli, Michela Baccini, Alessandra Mattei, Alberto Cipriani, Laura De Michieli, Aldostefano Porcari, Gianfranco Sinagra, Marco Merlo, Giacomo Tini, Beatrice Musumeci, Domitilla Russo, Pier Filippo Vianello, Marco Canepa, Roberto Licordari, Gianluca di Bella, Claudio Rapezzi, Federico Perfetto, Francesco Cappelli   +20 more
wiley   +1 more source

Val122Ile mt-ATTR Has a Worse Survival Than wt-ATTR Cardiac Amyloidosis

Journal of the American College of Cardiology, 2017
Maurer et al. [(1)][1] reported results from the THAOS (Transthyretin Amyloid Outcome Survey) registry of transthyretin cardiac amyloid (ATTR) amyloidosis, in which they compared differences between patients carrying wild-type ATTR (wt-ATTR) cardiac amyloidosis and those carrying the mutant ...
Avinainder, Singh, Hallie I, Geller, Rodney H, Falk   +2 more
openaire   +2 more sources

Transthyretin amyloid cardiomyopathy: Literature review and red‐flag symptom clusters for each cardiology specialty

ESC Heart Failure, Volume 12, Issue 2, Page 955-967, April 2025.
Abstract Wild‐type transthyretin amyloid cardiomyopathy (ATTRwt‐CM) is a progressive and infiltrative cardiac disorder that may cause fatal consequences if left untreated. The estimated survival time from diagnosis is approximately 3–6 years. Because of the non‐specificity of initial symptom manifestation and insufficient awareness among treating ...
Yasuhiro Izumiya, Toru Kubo, Jin Endo, Seiji Takashio, Masatoshi Minamisawa, Jun Hamada, Tomonori Ishii, Hajime Abe, Hiroaki Konishi, Kenichi Tsujita   +9 more
wiley   +1 more source

ATTR Variant Amyloidosis in Patients with Dysphagia

, 2023
Amyloidosis is a rare disease characterized by the accumulation of misfolded extracellular proteins in various organs. Over 30 precursor proteins have been identified that can form amyloid deposits in different parts of the body.
Christina Hui Lee Ng, Edward J. Damrose, Gerald J. Berry   +2 more
core   +1 more source

Prevalence of transthyretin cardiac amyloidosis in undifferentiated heart failure with preserved ejection fraction

ESC Heart Failure, Volume 12, Issue 2, Page 1176-1182, April 2025.
Abstract Aims Transthyretin amyloid cardiomyopathy (ATTR‐CM) is an increasinglyrecognized cause of heart failure with preserved ejection fraction (HFpEF), which may be diagnosed non‐invasively using 99mTc 3,3‐diphosphono‐1,2‐propanodicarboxylic acid (DPD) scintigraphy‐based diagnostic criteria.
L. Healy, G. Giblin, A. Gray, N. Starr, L. Murphy, D. O'Sullivan, E. Kavanagh, C. Howley, C. Tracey, E. Morrin, A. McDaid, A. Clarke, J.O. O'Neill, E. Joyce, M. O'Connell, N. G. Mahon   +15 more
wiley   +1 more source

Prevalence, incidence and clinical outcomes of epicardial coronary artery disease among transthyretin amyloidosis cardiomyopathy patients

BMC Cardiovascular Disorders, 2023
Background Transthyretin amyloidosis cardiomyopathy (ATTR-CM) patients are often older and may be at risk for obstructive epicardial coronary artery disease (oeCAD).
Rana Hassan, Robert J. H. Miller, Jonathan G. Howlett, James A. White, Nowell M. Fine   +4 more
doaj   +1 more source