Results 71 to 80 of about 17,377 (218)

Tafamidis decreased cardiac amyloidosis deposition in patients with Ala97Ser hereditary transthyretin cardiomyopathy: a 12-month follow-up cohort study

Orphanet Journal of Rare Diseases, 2023
Background Transthyretin cardiac cardiomyopathy (ATTR-CM) is a rare but life-threatening disease. Tafamidis is an effective treatment for patients with ATTR-CM, however its long-term effects on cardiac remodeling and cardiac amyloid deposition are ...
Cheng-Hsuan Tsai, Chi-Chao Chao, Sung-Tsang Hsieh, An-Li Yu, Yuan-Kun (Aden) Wu, Mei-Fang Cheng, Ming-Jen Lee, Chia-Hung Chou, Chia-Tung Shun, Hsueh-Wen Hsueh, Jimmy Jyh-Ming Juang, Ping-Huei Tseng, Mao-Yuan Su, Yen-Hung Lin   +13 more
doaj   +1 more source

Early Treatment of Cardiac ATTR

JACC: CardioOncology, 2022
[Figure: see text]
Daniel Lenihan, Richard K. Cheng
openaire   +2 more sources

Gene Editing for Haemophilia—The Next Frontier

Haemophilia, EarlyView.
ABSTRACT The recently approved haemophilia A and B gene therapies via adeno‐associated virus (AAV) showed a promising therapeutic response after a single injection, but there are still limitations, including the potential loss of transgene expression and restriction in adults.
Mirko Pinotti, Gregory A. Newby, Sundar Selvaraj, Steven W. Pipe   +3 more
wiley   +1 more source

Clinical Characteristics of FAP ATTR V30M and Control Patients.

, 2016
Clinical Characteristics of FAP ATTR V30M and Control Patients.
Yohei Misumi (3190254), Koutaro Takamatsu (425941), Yoshihiro Komohara (414247), Yukio Ando (559961), Masayoshi Tasaki (3190260), Mitsuharu Ueda (3190248), Satoru Senju (425942), Genki Suenaga (3190251), Tokunori Ikeda (425940), Takaaki Ito (676771), Tatsuyuki Kakuma (3190257)   +10 more
core   +1 more source

Role of FibroScan in evaluating hepatic involvement in systemic amyloidosis: a single‐centre prospective pilot study

Internal Medicine Journal, EarlyView.
Abstract Background Amyloidosis encompasses a group of diseases characterised by extracellular deposition of misfolded protein fibrils, potentially leading to organ dysfunction. Liver involvement occurs via direct amyloid infiltration, common in immunoglobulin light chain (AL) amyloidosis, or congestive hepatopathy, more typical in transthyretin (ATTR)
M Tang, N Vootukuru, J Tjahyadi, D Clayton Chubb, H Jina, SB Ting, S Bloom, R Sawhney, S Gibbs, O. Niewiadomski   +9 more
wiley   +1 more source

Mandatory and secondary procedures considered for classifying ATTR-CM and ATTR-CM-like cases.

Mandatory and secondary procedures considered for classifying ATTR-CM and ATTR-CM-like cases.
Fabio Fernandes (3386423), Isabella Zuppo Laper (17972784), Marcus Vinicius Simões (5224412), Claudenice Leite Bertoli de Souza (17972790), Ariane de Jesus Lopes de Abreu (14425084), Rafaela Vansan Ferreira (14425090), Edileide de Barros Correia (17972793), Guilherme Silva Julian (8520117), Cecilia Camacho-Hubner (17972787)   +8 more
core   +1 more source

Pittsburgh compound B positron emission tomography detects cardiomyopathy in hereditary transthyretin amyloidosis patients with negative bone scintigraphy: a pilot study

Frontiers in Nuclear Medicine
PurposeTo evaluate the effectiveness of positron emission tomography (PET) with [11C]-Pittsburgh Compound-B ([11C]PiB) for detecting transthyretin amyloid (ATTR) cardiomyopathy in patients with transthyretin gene (TTR) variants associated with reduced ...
Hendrea S. A. Tingen, Gilles N. Stormezand, Paul van Snick, Yingqi Hu, Paul Van Der Zwaag, Marish Oerlemans, Marish Oerlemans, Peter van der Meer, Bouke P. C. Hazenberg, Gert Luurtsema, Hans L. A. Nienhuis, Riemer H. J. A. Slart, Riemer H. J. A. Slart   +12 more
doaj   +1 more source

Diagnosis of Amyloidosis: A Survey of Current Awareness and Clinical Challenges Among Cardiologists in Switzerland

Cardiology and Therapy, 2020
Introduction Transthyretin amyloidosis (ATTR) is a progressive disease in which amyloid fibril deposition disrupts tissue structure and organ function. Many patients with ATTR present with cardiac involvement; recent studies indicate that ATTR prevalence
Dennis Mircsof
doaj   +1 more source

Feasibility of Left Bundle Branch Pacing and Management of Jailed Leads After Transcatheter Tricuspid Valve Implantation

Pacing and Clinical Electrophysiology, EarlyView.
ABSTRACT Atrioventricular conduction disturbances and the need for cardiac implantable electronic device (CIED) therapy are frequently required after transcatheter tricuspid valve implantation (TTVI). The interaction between the annulus, transcatheter heart valve and the leads is often complex and the optimal management under debate.
Thomas Seiler, Andreas Haeberlin, Domenico Angellotti, Joanna Bartkowiak, Nikola Kozhuharov, Boldizsar Kovacs, Stephan Windecker, Tobias Reichlin, Fabien Praz, Fabian Noti   +9 more
wiley   +1 more source

Genome‐Wide Association Study Elucidates the Genetic Architecture of Manganese Tolerance in Brassica napus

Plant, Cell &Environment, EarlyView.
ABSTRACT Brassica napus (canola) is a significant contributor to the world's oil production and is cultivated across continents, yet acidic soils with aluminium (Al3+) and manganese (Mn2+) toxicities limit its production. The genetic determinants underlying natural variation for acidic soil tolerance in canola are unknown and need to be determined ...
Harsh Raman, Zetao Bai, Brett McVittie, Sourav Mukherjee, Hugh D. Goold, Yuanyuan Zhang, Nay Chi Khin, Yu Qiu, Nawar Shamaya, Shengyi Liu, Regine Delourme, Barry J. Pogson, Sureshkumar Balasubramanian, Rosy Raman   +13 more
wiley   +1 more source