Results 71 to 80 of about 8,194 (217)

Reliability and validity of the Transthyretin Amyloidosis – Quality of Life (ATTR-QOL) Questionnaire impact scales

Journal of Patient-Reported Outcomes
Background The diversity of disease phenotypes associated with transthyretin (ATTR) amyloidosis poses challenges for measurement of health outcomes. The Transthyretin Amyloidosis – Quality of Life (ATTR-QOL) Questionnaire is a disease-specific patient ...
Andrew Lovley, Kristen Hsu, Kaitlin LaGasse, Isabelle Lousada, Kristen L. McCausland, Michelle K. Carty, Sabrina Rebello, Jakob B. Bjorner   +7 more
doaj   +1 more source

The Underscreening of Cardiac Amyloidosis in Patients With Pacemakers—A Single Centre Retrospective Audit

Journal of Cardiovascular Electrophysiology, EarlyView.
ABSTRACT Background Cardiac amyloidosis is commonly associated with cardiac conduction disease. We sought to determine the prevalence of advanced conduction disease requiring a pacemaker in patients with known cardiac amyloidosis to evaluate current screening practices among patients receiving pacemakers.
Peishan Cai, Timothy Scully, Jason Nogic, Kah Peck, Jithin Sajeev   +4 more
wiley   +1 more source

Transthyretin derived amyloid deposits in the atrium and the aortic valve: insights from multimodality evaluations and mid-term follow up

BMC Cardiovascular Disorders, 2023
Background Recent studies have reported atrial involvement and coexistence of aortic stenosis in transthyretin (ATTR) cardiac amyloidosis (CA). However, pathological reports of extraventricular ATTR amyloid deposits in atrial structures or heart valves ...
Atsushi Okada, Takashi Kakuta, Naoki Tadokoro, Emi Tateishi, Yoshiaki Morita, Takeshi Kitai, Makoto Amaki, Hideaki Kanzaki, Keiko Ohta-Ogo, Yoshihiko Ikeda, Satsuki Fukushima, Tomoyuki Fujita, Kengo Kusano, Teruo Noguchi, Chisato Izumi   +14 more
doaj   +1 more source

CARDIAC AND EXTRACARDIAC AMYLOIDOSIS IN V122I ATTR [PDF]

Journal of Neurology, Neurosurgery & Psychiatry, 2014
Introduction Hereditary transthyretin-related amyloidosis (ATTR) is a genetically heterogenous disease which may present with a predominant peripheral and autonomic neuropathy, a cardiac myopathy, or with both neurological and cardiac involvement. The V122I variant has a frequency of 3–4% in African Americans and causes 11% of cardiomyopathy in this ...
Aisling Carr, Z Jaunmuktane, Healy Pelayo, D Hutt, S Brandner Holton, J Blake, CJ Whelan, AD Wechalekar, JD Gilmore, PN Hawkins, MM Reilly   +10 more
openaire   +1 more source

Utilization and Prognosis of Cardiac Device Implantation in AL Versus ATTR Amyloidosis

Pacing and Clinical Electrophysiology, EarlyView.
ABSTRACT Introduction Cardiac amyloidosis can cause congestive heart failure, arrhythmias, and heart blocks, which frequently require cardiac device implantation (CDI). However, the differences between light chain (AL) amyloidosis and transthyretin (ATTR) amyloidosis CDI requirements are unknown. Methods A retrospective analysis was conducted using the
Bilal Hussain, Sanchit Duhan, Khawaja Hassan Akhtar, Amith Reddy Seri, Krittapoom Akrawinthawong, Janardhana Gorthi, Bijeta Keisham, Tarun Dasari   +7 more
wiley   +1 more source

Pittsburgh compound B positron emission tomography detects cardiomyopathy in hereditary transthyretin amyloidosis patients with negative bone scintigraphy: a pilot study

Frontiers in Nuclear Medicine
PurposeTo evaluate the effectiveness of positron emission tomography (PET) with [11C]-Pittsburgh Compound-B ([11C]PiB) for detecting transthyretin amyloid (ATTR) cardiomyopathy in patients with transthyretin gene (TTR) variants associated with reduced ...
Hendrea S. A. Tingen, Gilles N. Stormezand, Paul van Snick, Yingqi Hu, Paul Van Der Zwaag, Marish Oerlemans, Marish Oerlemans, Peter van der Meer, Bouke P. C. Hazenberg, Gert Luurtsema, Hans L. A. Nienhuis, Riemer H. J. A. Slart, Riemer H. J. A. Slart   +12 more
doaj   +1 more source

Semi-Quantitative Models for Identifying Potent and Selective Transthyretin Amyloidogenesis Inhibitors [PDF]

, 2017
Rate-limiting dissociation of the tetrameric protein transthyretin (TTR), followed by monomer misfolding and misassembly, appears to cause degenerative diseases in humans known as the transthyretin amyloidoses, based on human genetic, biochemical and ...
Choi, Sungwook, Connelly, Stephen, Johnson, Steven M., Kelly, Jeffery W., Mortenson, David E., Powers, Evan T., Wilson, Ian A.   +6 more
core   +2 more sources

Incidental detection of ATTR cardiac amyloidosis [PDF]

Journal of Nuclear Cardiology, 2022
Jessica A, Quaggin-Smith, Ramsey M, Wehbe, Thomas A, Holly   +2 more
openaire   +2 more sources

Advancing the Landscape of RNAi Nanotherapeutics for Ischemic Heart Disease

Advanced Materials, Volume 38, Issue 17, 20 March 2026.
RNA interference (RNAi) nanomedicine revolutionizes treatment regimens for ischemic heart diseases by enabling tailored, sequence‐anchored gene regulation. This review highlights the recent advances in nanotechnology‐driven RNAi therapeutics for myocardial ischemia and discusses the key design principles that govern efficient delivery, providing ...
Han Gao, Da Pan, Hélder A. Santos
wiley   +1 more source

Systemic Amyloidosis with Cardiac Involvement: Features of Course and Diagnostic Difficulties

Архивъ внутренней медицины
The diversity of clinical forms of amyloidosis is related to differences in amyloidogenic precursor proteins. Cardiac involvement is characteristic of AL- and ATTR-amyloidosis, with cardiac involvement developing in the vast majority of patients with AL ...
E. V. Voloshinova, I. Yu. Khorkina, A. M. Dzuban, E. V. Yakovleva   +3 more
doaj   +1 more source