Results 81 to 90 of about 134,165 (299)
Aging Is a Key Driver for Adult Acute Myeloid Leukemia
Aging and Cancer, EarlyView.Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley +1 more source
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
Hammond versus Ford radiation reaction force with the attractive Coulomb field [PDF]
, 2018 The classical central field is analyzed within the Hammond theory of radiation reaction force. For the attractive Coulomb field, the trajectories deduced from Ford and Hammond equations are numerically obtained.
E. Salinas-Hernández +2 more
core +1 more source
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
Repulsive and attractive critical Casimir forces [PDF]
, 2007 International audienceWhen confining vacuum fluctuations between two identical walls, the Casimir force manifests itself as a mutual attraction of the walls.
Rafai, S.C. +5 more
core +1 more source
Arthritis Care &Research, EarlyView.Objective This study aimed to investigate hand function trajectories over five years in primary hand osteoarthritis (OA). Additionally, determinants of baseline and longitudinal hand function were assessed. Methods A total of 538 patients with both baseline and five‐year study visits were analyzed.
Annemiek V. E. M. Olde Meule +4 more
wiley +1 more source
Attractive Behavior of Conductive Like-Charged DustGrains In a Plasma [PDF]
, 2021 In this thesis, the attractive behavior of like-charged dust grains is investigated. A theoreticalmathematical formulation for an attractive model of electrostatic forces between two dust grains isexamined. A theoretical model of the shadow ...
Cage, Brandon
core +3 more sources
The Attractive Force of the Atom in Combination [PDF]
Scientific American, 1877 n ...
openaire +1 more source
Attractive Force and Magnetic Induction [PDF]
Physical Review (Series I), 1902 n ...
openaire +1 more source
Arthritis Care &Research, EarlyView.Over the past 50 years, the science of pediatric rheumatology has grown exponentially due to an expansion in the understanding of complex rheumatic conditions and a surge in novel targeted therapeutics. Physician‐scientists in the field of pediatric rheumatology have played major roles in these advancements that have improved the care of children ...
Ekemini A. Ogbu +2 more
wiley +1 more source