Results 51 to 60 of about 669,840 (357)
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
Survivin and Aurora Kinase A control cell fate decisions during mitosis
Molecular Oncology, EarlyView.Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir +2 more
wiley +1 more source
Stability and attractivity for Nicholson systems with time-dependent delays
, 2017 We analyse the stability and attractivity of a class of n-dimensional Nicholson systems with constant coefficients and multiple time-varying delays. Delayindependent sufficient conditions on the coefficients are given, for the existence and absolute ...
Diogo M. Caetano, T. Faria
semanticscholar +1 more source
Sufficient Conditions for Temporal Logic Specifications in Hybrid Dynamical Systems. [PDF]
, 2018 In this paper, we introduce operators, semantics, and conditions that, when possible, are solution-independent to guarantee basic temporal logic specifications for hybrid dynamical systems.
Han, Hyejin, Sanfelice, Ricardo G
core
A dual modelling of evolving political opinion networks
, 2012 We present the result of a dual modeling of opinion network. The model complements the agent-based opinion models by attaching to the social agent (voters) network a political opinion (party) network having its own intrinsic mechanisms of evolution ...
D. Stauffer +5 more
core +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Existence and attractivity of solutions for fractional difference equations
Advances in Differential Equations, 2018 In this paper, we study a kind of difference equations with Riemann–Liouville-like fractional difference. The results on existence and attractivity are obtained by using the Picard iteration method and Schauder’s fixed point theorem.
Lu Zhang, Yong Zhou
semanticscholar +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Demonstratio Mathematica, 2016 In this paper, we construct a non-standard finite difference scheme for a general model of glucose-insulin interaction. We establish some new sufficient conditions to ensure that the discretized model preserves the persistence and global attractivity of ...
Huong Dinh Cong
doaj +1 more source
Reduction of Order, Periodicity and Boundedness in Nonlinear, Higher Order Difference Equations
, 2012 We consider the semiconjugate factorization and reduction of order for non-autonomous, nonlinear, higher order difference equations containing linear arguments. These equations have appeared in several mathematical models in biology and economics.
Sedaghat, H.
core +1 more source