Results 81 to 90 of about 42,095 (253)

On the underlying assumptions of threshold Boolean networks as a model for genetic regulatory network behavior

open access: yesFrontiers in Genetics, 2013
Boolean networks (BoN) are relatively simple and interpretable models of gene regulatorynetworks. Specifying these models with fewer parameters while retaining their ability to describe complex regulatory relationships is an ongoing methodological ...
Van eTran   +3 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Photoplethysmogram beat detection using Symmetric Projection Attractor Reconstruction

open access: yesFrontiers in Physiology
Many methods have been proposed to detect beats in photoplethysmogram (PPG) signals. We present a novel method which uses the Symmetric Projection Attractor Reconstruction (SPAR) method to generate an attractor in a two dimensional phase space from the ...
Callum Pettit   +2 more
doaj   +1 more source

SELF-EQUALITY AS A STRATEGY OF SPONTANEOUS TEXT GENERATION

open access: yesВестник Кемеровского государственного университета, 2017
The article deals with the results of the psycholinguistic experiment which prove the influence of the self-equality strategy in the process of spontaneous reaction text generation as a reaction on the stimulus “human life”.
G. G. Moskaltchuk
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

The Lorenz attractor exists

open access: yes, 1999
We prove that the Lorenz equations support a strange attractor, as conjectured by Edward Lorenz in 1963. We also prove that the attractor is robust, i.e., it persists under small perturbations of the coefficients in the underlying differential equations.
Tucker, Warwick
core  

Universal Attractor for Inflation at Strong Coupling [PDF]

open access: yes, 2014
We introduce a novel nonminimal coupling between gravity and the inflaton sector. Remarkably, for large values of this coupling all models asymptote to a universal attractor.
Roest, Diederik   +3 more
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

Distance in Visual Memory Phase Space Predicts Skill Acquisition Time: Evidence from Simulations of a Deep Neural Network

open access: yesMathematics
It is proposed that the process of learning may be represented as a trajectory within the phase space of long-term memory. The research uses an artificial neural network design to explore, in theory, if starting from different points within the phase ...
Philippe Chassy
doaj   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

open access: yesMolecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens   +6 more
wiley   +1 more source

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