Results 81 to 90 of about 107,710 (292)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Vanishing of local non-Gaussianity in canonical single field inflation
, 2018 We study the production of observable primordial local non-Gaussianity in two opposite regimes of canonical single field inflation: attractor (standard single field slow-roll inflation) and non attractor (ultra slow-roll inflation).
Bravo, Rafael +3 more
core +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Dynamics on a class of f(R,T) cosmology
上海师范大学学报. 自然科学版, 2014 In this paper,the dynamical analysis is performed for a spatially flat universe governed by a special model of f(R,T) gravity.The critical points are classified and a three-dimensional attractor is found.Especially,in the case of T=0,the phase ...
GE Feifei
doaj +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Features from the non-attractor beginning of inflation
, 2016 We study the effects of the non-attractor initial conditions for the canonical single-field inflation. The non-attractor stage can last only several $e$-folding numbers, and should be followed by hilltop inflation. This two-stage evolution leads to large
Cai, Yi-Fu +3 more
core +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Attractor – a new turning point in drug discovery
Drug Design, Development and Therapy, 2019 Xucan Hou, Meng Li, Congmin Jia, Xianbao Zhang, Yun WangDepartment of Traditional Chinese Medicine Information Fusion and Utilization, Beijing University of Chinese Medicine, Beijing, People’s Republic of ChinaCorrespondence: Yun WangDepartment of ...
Hou X, Li M, Jia C, Zhang X, Wang Y
doaj
The multipliers of periodic points in one-dimensional dynamics
, 1998 It will be shown that the smooth conjugacy class of an $S-$unimodal map which does not have a periodic attractor neither a Cantor attractor is determined by the multipliers of the periodic orbits.
Blokh A M +11 more
core +1 more source