Results 91 to 100 of about 107,710 (292)

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Analyzing Convergence in Sequences of Uncountable Iterated Function Systems—Fractals and Associated Fractal Measures

Mathematics
In this paper, we examine a sequence of uncountable iterated function systems (U.I.F.S.), where each term in the sequence is constructed from an uncountable collection of contraction mappings along with a linear and continuous operator.
Ion Mierluș–Mazilu, Lucian Niță
doaj   +1 more source

Attractor Behavior of Phantom Cosmology

, 2005
We investigate the cosmological attractor of the minimally coupled, self-interacting phantom field with a positive energy density but negative pressure.
Aguirregabiria, Barrow, Bastero-Gil, Caldwell, Caldwell, Carroll, Chiba, Dabrowski, Frampton, Gibbons, Guo, Guo, Guo, Guo, Kehagias, Liddle, Lidsey, Meng, Mersini, Nojiri, Nojiri, Piao, Piao, Pollock, Sami, Schulz, Singh, Torres, Yuan-Zhong Zhang, Yun-Song Piao, Zong-Kuan Guo   +30 more
core   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Global attractors of evolutionary systems [PDF]

, 2006
An abstract framework for studying the asymptotic behavior of a dissipative evolutionary system $\mathcal{E}$ with respect to weak and strong topologies was introduced in [8] primarily to study the long-time behavior of the 3D Navier-Stokes equations ...
Cheskidov, Alexey
core  

Incidence of nonextensive thermodynamics in temporal scaling at Feigenbaum points

, 2006
Recently, in Phys. Rev. Lett. 95, 140601 (2005), P. Grassberger addresses the interesting issue of the applicability of q-statistics to the renowned Feigenbaum attractor.
A. Robledo, Anania, Añaños, Baldovin, Baldovin, Baldovin, Baldovin, Beck, Borges, Buiatti, Casati, Coraddu, Coraddu, Costa, de Moura, Eckmann, Farmer, Fujisaka, Grassberger, Grassberger, Halsey, Hata, Hilborn, Horita, Latora, Latora, Lyra, Mayoral, Mayoral, Montangero, Mori, Paladin, Robledo, Robledo, Robledo, Robledo, Sano, Schuster, Tirnakli, Tonelli, Tsallis, Tsallis, Yang   +42 more
core   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Attractor Metadynamics in Adapting Neural Networks

, 2014
Slow adaption processes, like synaptic and intrinsic plasticity, abound in the brain and shape the landscape for the neural dynamics occurring on substantially faster timescales.
C. Gros, C. Gros, C. Gros, C.J. Honey, D. Marković, E. Marder, E. Russo, E.T. Jaynes, G. Daoudal, G. Deco, G.G. Turrigiano, J. Triesch, J.J. Hopfield, J.J. Steil, M. Linkerhand, N. Ulanovsky, R.D. Beer, R.D. Beer, R.D. Beer, T. O’Leary   +19 more
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source