Results 91 to 100 of about 42,095 (253)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Visualizing the transition to chaos in the Lorenz system [PDF]
, 2006 The Lorenz system still fascinates many people because of the simplicity of the equations that generate such complicated dynamics on the famous butterfly attractor.
Osinga, HM +3 more
core
A 3-D spherical chaotic attractor [PDF]
, 2011 : A simple smooth chaotic system, which showed a 3-layer sphere chaotic attractor, is investigated. It is found that this chaotic attractor is a limit cycle instead of chaotic attractor. This situation was caused by the simulation time which is too short
Wang, Zenghui. +5 more
core +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Lower semicontinuity of attractors for non-autonomous dynamical systems [PDF]
, 2009 This paper is concerned with the lower semicontinuity of attractors for semilinear non-autonomous differential equations in Banach spaces. We require the unperturbed attractor to be given as the union of unstable manifolds of time-dependent hyperbolic
Langa, José A. +3 more
core +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Upper, down, two-sided Lorenz attractor, collisions, merging and switching [PDF]
, 2021 We present a slightly modified version of the well known "geometric Lorenz attractor". It consists in a C1 open set O of vector fields in R3 having an attracting region U containing: (1) a unique singular saddle point sigma; (2) a unique attractor Lambda
Bonatti, C. +3 more
core
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
On the Computation of the Hausdorff Dimension of the Walrasian Economy:Further Notes [PDF]
: In a recent paper, Dominique (2009) argues that for a Walrasian economy with m consumers and n goods, the equilibrium set of prices becomes a fractal attractor due to continuous destructions and creations of excess demands.
Dominique, C-Rene
core
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source