Results 61 to 70 of about 3,221,975 (292)

Geometry of neural dynamics along the cortical attractor landscape reflects changes in attention

open access: yesNature Communications
Large-scale brain activity reflects changes in attention. To understand how, we tested a hypothesis that the geometry of neural dynamics on the cortical attractor landscape, or movement along its “hills and valleys”, reflects attentional states.
Hayoung Song   +6 more
doaj   +1 more source

H1-Random Attractors and Asymptotic Smoothing Effect of Solutions for Stochastic Boussinesq Equations with Fluctuating Dynamical Boundary Conditions

open access: yesAbstract and Applied Analysis, 2013
This work is concerned with the random dynamics of two-dimensional stochastic Boussinesq system with dynamical boundary condition. The white noises affect the system through a dynamical boundary condition.
Yijin Zhang
doaj   +1 more source

On three types of dynamics and the notion of attractor [PDF]

open access: yesProceedings of the Steklov Institute of Mathematics, 2017
We propose a theoretical framework for an explanation of the numerically discovered phenomenon of the attractor-repeller merger. We identify regimes which are observed in dynamical systems with attractors as defined in a work by Ruelle and show that these attractors can be of three different types. The first two types correspond to th ewell-known types
Turaev, D, Gonchenko, S
openaire   +3 more sources

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

open access: yesFEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt   +8 more
wiley   +1 more source

Recurrent circuitry is required to stabilize piriform cortex odor representations across brain states

open access: yeseLife, 2020
Pattern completion, or the ability to retrieve stable neural activity patterns from noisy or partial cues, is a fundamental feature of memory. Theoretical studies indicate that recurrently connected auto-associative or discrete attractor networks can ...
Kevin A Bolding   +4 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

Vibration-based damage detection in structures using time series analysis [PDF]

open access: yes, 2006
The paper considers some possibilities to use pure time series analysis for damage diagnosis in vibrating structures. It introduces the basics of the state space methodology and discusses a number of possible methods to extract damage sensitive features ...
Trendafilova, I.
core   +3 more sources

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

open access: yesFEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge   +6 more
wiley   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

open access: yesFEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

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