Results 81 to 90 of about 3,221,975 (292)

Attractor-Map Versus Autoassociation Based Attractor Dynamics in the Hippocampal Network

Journal of Neurophysiology, 2010
The autoassociative memory model of hippocampal field CA3 postulates that Hebbian associations among external input features produce attractor states embedded in a recurrent synaptic matrix. In contrast, the attractor-map model postulates that a two-dimensional continuum of attractor states is preconfigured in the network during development and that ...
Colgin, L. L., Leutgeb, S., Jezek, K., Leutgeb, J. K., Moser, E. I., McNaughton, B. L., Moser, M.-B.   +6 more
openaire   +3 more sources

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

On Cognition as Dynamical Coupling: An Analysis of Behavioral Attractor Dynamics

Adaptive Behavior, 2008
The interaction of brain, body, and environment can result in complex behavior with rich dynamics, even for relatively simple agents. Such dynamics are, however, often difficult to analyze. In this article, we explore the case of a simple simulated robotic agent, equipped with a reactive neurocontroller and an energy level, which the agent has been ...
Alberto Montebelli, Carlos Herrera Pérez, Tom Ziemke   +2 more
openaire   +3 more sources

Relationship between network dynamics and deformation of the attractor landscape.

, 2019
(A-D) ACh-controlled deformation of the attractor landscape. When ACh is released, the inhibition rate REI decreases because of disinhibition of inhibitory synapses projecting onto excitatory neurons.
Takashi Kanamaru (289509), Kazuyuki Aihara (44090)   +1 more
core   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Design and Analysis of a Quadratic Lorenz-like Attractor for Pseudo-Random Number Generation

Cumhuriyet Science Journal
This study introduces and analyzes a novel quadratic Lorenz-like attractor and demonstrates its application as a pseudo-random number generator (PRNG). A theoretical and numerical investigation of the system dynamics is conducted, including equilibrium ...
Bugce Eminaga Tatlicioglu, Hatice Aktöre   +1 more
doaj   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Learning Attractor Dynamics for Generative Memory

CoRR, 2018
A central challenge faced by memory systems is the robust retrieval of a stored pattern in the presence of interference due to other stored patterns and noise. A theoretically well-founded solution to robust retrieval is given by attractor dynamics, which iteratively clean up patterns during recall. However, incorporating attractor dynamics into modern
Yan Wu 0010, Gregory Wayne, Karol Gregor, Timothy P. Lillicrap   +3 more
openaire   +3 more sources

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source