Results 141 to 150 of about 897,554 (368)

Functional attractors in microbial community assembly.

open access: yesCell Systems, 2021
Sylvie Estrela   +8 more
semanticscholar   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola   +12 more
wiley   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

open access: yesMolecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken   +7 more
wiley   +1 more source

Polynomial $\alpha$-attractors

open access: yes, 2022
Inflationary $\alpha$-attractor models can be naturally implemented in supergravity with hyperbolic geometry. They have stable predictions for observables, such as $n_s=1-{2/ N_e} $, assuming that the potential in terms of the original geometric variables, as well as its derivatives, are not singular at the boundary of the hyperbolic disk, or half ...
Kallosh, Renata, Linde, Andrei
openaire   +2 more sources

Periodic Random Attractors for Stochastic Navier-Stokes Equations on Unbounded Domains

open access: yes, 2012
This paper is concerned with the asymptotic behavior of solutions of the two-dimensional Navier-Stokes equations with both non-autonomous deterministic and stochastic terms defined on unbounded domains.
Wang, Bixiang
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Modern Handball: A Dynamic System, Orderly Chaotic

open access: yesApplied Sciences
(1) Background: Handball is conceptualized as a complex dynamic system characterized by emergent behaviors, non-linearity, attractors, and self-organization, influenced by players’ interactions, environmental conditions, and tactical elements.
Sebastián Espoz-Lazo   +1 more
doaj   +1 more source

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