Results 121 to 130 of about 87,240 (291)
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Polynomial $\alpha$-attractors
, 2022 Inflationary $\alpha$-attractor models can be naturally implemented in supergravity with hyperbolic geometry. They have stable predictions for observables, such as $n_s=1-{2/ N_e} $, assuming that the potential in terms of the original geometric variables, as well as its derivatives, are not singular at the boundary of the hyperbolic disk, or half ...
Kallosh, Renata, Linde, Andrei
openaire +2 more sources
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Modeling Networks of Four Elements
ComputationIn this article, fourth-order systems of ordinary differential equations are studied. These systems are of a special form, which is used in modeling gene regulatory networks.
Olga Kozlovska, Felix Sadyrbaev
doaj +1 more source
Periodic Random Attractors for Stochastic Navier-Stokes Equations on Unbounded Domains
, 2012 This paper is concerned with the asymptotic behavior of solutions of the two-dimensional Navier-Stokes equations with both non-autonomous deterministic and stochastic terms defined on unbounded domains.
Wang, Bixiang
core +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Mega-History and the 21st century singularity puzzle [PDF]
Философия и космология, 2015 A series of calculations carried out independently by the Australian, Russian and American re- searchers have demonstrated that a crucial global polyfurcation is expected near the middle of the 21st century. This result is drawn by extrapolating into the
Akop P. Nazaretyan
doaj
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Қарағанды университетінің хабаршысы. Математика сериясыWe consider the reaction–diffusion system of equations with rapidly oscillating terms in the equation and in boundary conditions in a domain with locally periodic oscillating boundary.
G.F. Azhmoldaev +3 more
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Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source