Results 91 to 100 of about 846,763 (295)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Protecting built property against fire disasters: Multi ‐attribute decision making with respect to fire risk

International Journal of Strategic Property Management, 2010
The protection of buildings against fire disasters may require a comparison of alternative fire safety designs. The fire safety solutions can be compared by means of a general methodology known as multi‐attribute selection or multi‐criteria decision ...
Egidijus Rytas Vaidogas, Jurgita Šakėnaitė   +1 more
doaj   +1 more source

Multi-Label Attribute Selection of Arrhythmia for Electrocardiogram Signals with Fusion Learning. [PDF]

Bioengineering (Basel), 2022
Yang J, Li J, Lan K, Wei A, Wang H, Huang S, Fong S.   +6 more
europepmc   +1 more source

Improving Lazy Attribute Selection

Journal of Information and Data Management, 2011
Attribute selection is a data preprocessing step which aims at identifying relevant attributes for a target data mining task - specifically in this article, the classification task. Previously, we have proposed a new attribute selection strategy - based on a lazy learning approach - which postpones the identification of relevant attributes until an ...
Pereira, Rafael B., Plastino, Alexandre, Zadrozny, Bianca, Merschmann, Luiz H. de C., Freitas, Alex A.   +4 more
openaire   +2 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Suite of decision tree-based classification algorithms on cancer gene expression data

Egyptian Informatics Journal, 2011
One of the major challenges in microarray analysis, especially in cancer gene expression profiles, is to determine genes or groups of genes that are highly expressed in cancer cells but not in normal cells. Supervised machine learning techniques are used
Mohmad Badr Al Snousy, Hesham Mohamed El-Deeb, Khaled Badran, Ibrahim Ali Al Khlil   +3 more
doaj   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

TOPSIS Method for Probabilistic Linguistic MAGDM with Entropy Weight and Its Application to Supplier Selection of New Agricultural Machinery Products

Entropy, 2019
In multiple attribute group decision making (MAGDM) problems, uncertain decision information is well-represented by linguistic term sets (LTSs). These LTSs are easily converted into probabilistic linguistic sets (PLTSs). In this paper, a TOPSIS method is
Jianping Lu, Cun Wei, Jiang Wu, Guiwu Wei   +3 more
doaj   +1 more source

THE EFFECT OF RISK AND AUTONOMY ON INDEPENDENT HOG PRODUCERS' CONTRACTING DECISIONS [PDF]

The introduction of vertical coordination in the hog industry has provided producers with new business arrangements for raising hogs. While some researchers have elicited utility functions for hog producers on the basis of income risk, none have ...
Eidman, Vernon R., Gillespie, Jeffrey M.
core   +1 more source

Feature selection methods for solving the reference class problem [PDF]

, 2010
Probabilistic inference from frequencies, such as "Most Quakers are pacifists; Nixon is a Quaker, so probably Nixon is a pacifist" suffer from the problem that an individual is typically a member of many "reference classes" (such as Quakers, Republicans,
Franklin, James
core