Results 81 to 90 of about 168,976 (322)
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Integrating Sensitizing Labs in an Educational Design Process for Haptic Interaction
FORMakademisk, 2016 New design methods for educating designers are needed to adapt the attributes of haptic interaction to fit the embodied experience of the users. This paper presents educationally framed aesthetic sensitizing labs: 1) a material-lab exploring the tactile ...
Cheryl Akner-Koler, Parivash Ranjbar
doaj +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Multiple-Robot Systems for USAR: Key Design Attributes and Deployment Issues
International Journal of Advanced Robotic Systems, 2011 The interaction between humans and robots is undergoing an evolution. Progress in this evolution means that humans are close to robustly deploying multiple robots. Urban search and rescue (USAR) can benefit greatly from such capability.
Choon Yue Wong +2 more
doaj +2 more sources
Information Quality Framework for e-Learning Systems
Knowledge Management & E-Learning: An International Journal, 2010 Information quality frameworks are developed to measure the quality of information systems, generally from the designers’ viewpoint. The recent proliferation of e-services and e-learning particularly raises the need for a new quality framework in the ...
Mona Alkhattabi +2 more
doaj
The Influence of Design Team Attributes on Green Design Performance of Building Projects
Environmental Management and Sustainable Development, 2012 The design phase is the most important phase in determining the green performance of building projects. The performance of the design team is crucial. The growing importance of sustainability globally necessitates the inclusion of green criteria in the design team selection process.
Mohamed S. Elforgani, Ismail Bin Rahmat
openaire +2 more sources
An intelligent approach to design three-dimensional aircraft sheet metal part model for manufacture [PDF]
, 2013 Aircraft sheet metal part manufacturing is a knowledge-intensive process, and the manufacturability and manufacturing information are required to be considered in three-dimensional (3D) model by knowledge reuse.
Chen, Hui +3 more
core
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Expert System Approach for Manufacturability Evaluation of Nd: YAG Laser Beam Machining Process [PDF]
International Journal of Advanced Design and Manufacturing Technology, 2017 In this paper, an expert system (ES) is developed for manufacturability evaluation of ND:YAG laser in computer based concurrent engineering. The expert system evaluates machining cycle time and cost in less than 30 seconds.
M. Sadegh Amalnik*
doaj
Required Project Designers' Attributes as Perceived by Male and Female Engineers
, 2021 Petros Kritikos +2 more
openalex +1 more source