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Plasmatherapy in Atypical Hemolytic Uremic Syndrome
Seminars in Thrombosis and Hemostasis, 2010Plasmatherapy has become empirically first-line treatment in atypical hemolytic uremic syndrome (aHUS), although no prospective controlled trials have been conducted. Patients with mutations that induce complete or partial factor H (FH) quantitative deficiency may be controlled by plasma infusions (PI), but plasma exchanges appear more efficient than ...
Chantal Loirat +2 more
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Atypical hemolytic uremic syndrome
Current Opinion in Hematology, 2010The last few years revealed a molecular distinction between thrombotic thrombocytopenic purpura, a disease characterized by a lack of ADAMTS13 activity, and atypical hemolytic uremic syndrome (aHUS), a disease of complement overactivation. Many different predisposing genetic factors resulting in complement overactivation have been described in aHUS ...
Kavanagh D, Goodship THJ
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Eculizumab for Atypical Hemolytic Uremic Syndrome in Pregnancy
Obstetrics & Gynecology, 2013Atypical hemolytic uremic syndrome (HUS) is a thrombotic microangiopathy often caused by mutations in complement genes. During pregnancy, disease outcome is poor both for mother and fetus. Since 2009, the humanized monoclonal antibody eculizumab has been successfully used in the treatment of atypical HUS in nonpregnant patients.A 26-year-old woman with
G. Ardissino +4 more
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Atypical hemolytic uremic syndrome in the Tunisian population
International Urology and Nephrology, 2010Hemolytic uremic syndrome consists of a triad of acquired hemolytic anemia, thrombocytopenia and renal failure.Our objectives were to determine epidemiology, clinical and laboratory characteristics of patients with atypical hemolytic uremic syndrome (aHUS) to determine the relationship between the complement protein deficit and aHUS in the Tunisian ...
Nadia, Leban +11 more
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Posttransplant recurrence of atypical hemolytic uremic syndrome
Journal of Nephrology, 2012Hemolytic uremic syndrome (HUS) is a rare disease characterized by microangiopathic hemolytic anemia, thrombocytopenia and acute renal failure. It is usually secondary to infections by strains of Escherichia coli (STEC) that produce Shiga-like toxin. In about 10% of patients, no STEC infections are reported.
Elisabetta, Valoti +2 more
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Hypertensive choroidopathy in atypical hemolytic-uremic syndrome
European Journal of Ophthalmology, 2019Purpose: We present the case of a 22-year-old woman, diagnosed as having atypical hemolytic uremic syndrome with a hypertensive crisis, who presented a bilateral serous retinal detachment. Case Description: A 22-year-old woman ...
Maria Sole Polito +3 more
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Atypical hemolytic uremic syndrome: a clinical conundrum
Pediatric Nephrology, 2016Patients negative for Shiga toxin-producing E. coli (STEC) are categorized as having atypical hemolytic uremic syndrome (HUS) and are associated with an increased risk for complement mutations and poorer prognosis compared with typical HUS. However, STEC identification is limited by the natural history of HUS.The current study is aimed at identifying ...
Prabesh, Bajracharya +4 more
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