Results 31 to 40 of about 23,203 (49)

Otoferlin Is Required for Proper Synapse Maturation and for Maintenance of Inner and Outer Hair Cells in Mouse Models for DFNB9

Frontiers in Cellular Neuroscience, 2021
Deficiency of otoferlin causes profound prelingual deafness in humans and animal models. Here, we closely analyzed developmental deficits and degenerative mechanisms in Otof knock-out (Otof–/–) mice over the course of 48 weeks.
Ursula Stalmann, Albert Justin Franke, Hanan Al-Moyed, Nicola Strenzke, Ellen Reisinger, Ellen Reisinger   +5 more
doaj   +1 more source

Human Brainstem Exhibits higher Sensitivity and Specificity than Auditory-Related Cortex to Short-Term Phonetic Discrimination Learning

Scientific Reports, 2017
Phonetic discrimination learning is an active perceptual process that operates under the influence of cognitive control mechanisms by increasing the sensitivity of the auditory system to the trained stimulus attributes.
Stefan Elmer, Marcela Hausheer, Joëlle Albrecht, Jürg Kühnis   +3 more
doaj   +1 more source

Quantitative optical nanophysiology of Ca2+ signaling at inner hair cell active zones

Nature Communications, 2018
Quantitatively studying components of the presynapse requires high resolution optical methods. Here the authors use confocal microscopy as well as 2D- and 3D-STED nanoscopy to quantify the number and activity of active zone Ca2+ channels in inner hair ...
Jakob Neef, Nicolai T. Urban, Tzu-Lun Ohn, Thomas Frank, Philippe Jean, Stefan W. Hell, Katrin I. Willig, Tobias Moser   +7 more
doaj   +1 more source

Gene therapy for deafness: are we there now?

EMBO Molecular Medicine
Approximately half a billion people—5% of the world’s population—suffer from disabling hearing impairment (HI) according to the WHO ( http://www.who.int/features/factfiles/deafness/en/ ).
Tobias Moser, Han Chen, Kathrin Kusch, Rüdiger Behr, Barbara Vona   +4 more
doaj   +1 more source

Optical measurement of glutamate release robustly reports short-term plasticity at a fast central synapse

Frontiers in Molecular Neuroscience
IntroductionRecently developed fluorescent neurotransmitter indicators have enabled direct measurements of neurotransmitter in the synaptic cleft. Precise optical measurements of neurotransmitter release may be used to make inferences about presynaptic ...
Paul Jakob Habakuk Hain, Paul Jakob Habakuk Hain, Tobias Moser, Tobias Moser   +3 more
doaj   +1 more source

The impact of visual gaze direction on auditory object tracking

Scientific Reports, 2017
Subjective experience suggests that we are able to direct our auditory attention independent of our visual gaze, e.g when shadowing a nearby conversation at a cocktail party. But what are the consequences at the behavioural and neural level?
Ulrich Pomper, Maria Chait
doaj   +1 more source

Intrinsic and Synaptic Dynamics Contribute to Adaptation in the Core of the Avian Central Nucleus of the Inferior Colliculus

Frontiers in Neural Circuits, 2019
The reduction of neuronal responses to repeated stimulus presentation occurs in many sensory neurons, also in the inferior colliculus of birds. The cellular mechanisms that cause response adaptation are not well described.
Sebastian T. Malinowski, Sebastian T. Malinowski, Jana Wolf, Thomas Kuenzel   +3 more
doaj   +1 more source

Management of tegmen defects with mastoid and epitympanic obliteration using S53P4 bioactive glass

Laryngoscope Investigative Otolaryngology, 2020
Objective To evaluate the surgical results and complications in a cohort of patients operated on to repair a tegmen bony defect using either transmastoid approach with obliteration using S53P4 bioactive glass granules (TMA‐O), or the classic middle ...
Françoise Remangeon, Ghizlene Lahlou, Lauranne Alciato, Frederic Tankere, Isabelle Mosnier, Olivier Sterkers, Nadya Pyatigorskaya, Daniele Bernardeschi   +7 more
doaj   +1 more source

Aging affects the balance of neural entrainment and top-down neural modulation in the listening brain

Nature Communications, 2017
The changes that accompany age-related decreases in speech comprehension are not yet understood. Here, authors show that older adults are less able to entrain to speech-paced auditory rhythms and that the behavioural consequences can be counteracted by ...
Molly J. Henry, Björn Herrmann, Dunja Kunke, Jonas Obleser   +3 more
doaj   +1 more source

New insights into cochlear sound encoding [version 1; referees: 2 approved]

F1000Research, 2016
The inner ear uses specialized synapses to indefatigably transmit sound information from hair cells to spiral ganglion neurons at high rates with submillisecond precision.
Tobias Moser, Christian Vogl
doaj   +1 more source