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Towards the optical cochlear implant: optogenetic approaches for hearing restoration [PDF]
EMBO Molecular Medicine, 2020 Cochlear implants (CIs) are considered the most successful neuroprosthesis as they enable speech comprehension in the majority of half a million CI users suffering from sensorineural hearing loss.
Alexander Dieter +2 more
doaj +3 more sources
Perspectives on Human Hearing Loss, Cochlear Regeneration, and the Potential for Hearing Restoration Therapies [PDF]
Brain Sciences, 2020 Most adults who acquire hearing loss find it to be a disability that is poorly corrected by current prosthetics. This gap drives current research in cochlear mechanosensory hair cell regeneration and in hearing restoration.
Patricia M. White
doaj +4 more sources
The Myc Road to Hearing Restoration [PDF]
Cells, 2012 Current treatments for hearing loss, the most common neurosensory disorder, do not restore perfect hearing. Regeneration of lost organ of Corti hair cells through forced cell cycle re-entry of supporting cells or through manipulation of stem cells, both ...
Bernd Fritzsch, Benjamin Kopecky
doaj +5 more sources
Sound Strategies for Hearing Restoration [PDF]
Science, 2014 Hearing Aid Many millions of people across the globe are subject to hearing loss. Géléoc and Holt ( 10.1126/science.1241062 ) review recent developments in potential therapeutic strategies to restore inner-ear function in patients with acquired or genetic forms of deafness.
Gwenaelle S G Geleoc, Jeffrey R Holt
exaly +5 more sources
Hearing Restoration with Auditory Brainstem Implant [PDF]
Neurologia Medico-Chirurgica, 2016 Auditory brainstem implant (ABI) technology attempts to restore hearing in deaf patients caused by bilateral cochlear nerve injury through the direct stimulation of the brainstem, but many aspects of the related mechanisms remain unknown. The unresolved issues can be grouped into three topics: which patients are the best candidates; which type of ...
Hirofumi Nakatomi +2 more
exaly +5 more sources
Recent Advancements in the Regeneration of Auditory Hair Cells and Hearing Restoration [PDF]
Frontiers in Molecular Neuroscience, 2017 Neurosensory responses of hearing and balance are mediated by receptors in specialized neuroepithelial sensory cells. Any disruption of the biochemical and molecular pathways that facilitate these responses can result in severe deficits, including ...
Rahul Mittal +9 more
doaj +4 more sources
Is there an unmet medical need for improved hearing restoration? [PDF]
EMBO Molecular Medicine, 2022 Hearing impairment, the most prevalent sensory deficit, affects more than 466 million people worldwide (WHO). We presently lack causative treatment for the most common form, sensorineural hearing impairment; hearing aids and cochlear implants (CI) remain
Bettina Julia Wolf +7 more
doaj +2 more sources
Hearing restoration and the stria vascularis: evidence for the role of the immune system in hearing restoration. [PDF]
Curr Opin Otolaryngol Head Neck Surg, 2021 Purpose of review This article reviews the current literature regarding the pathogenesis of immune-mediated sensorineural hearing loss, utilizes previously published single-nucleus transcriptional profiles to characterize cytokine and cytokine receptor expression in the adult stria vascularis cell types to support immune system
Samaha NL, Almasri MM, Johns JD, Hoa M.
europepmc +3 more sources
Frontiers in Molecular Neuroscience, 2021 Clinical management of auditory synaptopathies like other genetic hearing disorders is currently limited to the use of hearing aids or cochlear implants.
David Oestreicher +12 more
doaj +1 more source
Computational and Structural Biotechnology Journal, 2022 When hearing fails, electrical cochlear implants (eCIs) partially restore hearing by direct stimulation of spiral ganglion neurons (SGNs). As light can be better confined in space than electrical current, optical CIs (oCIs) provide more spectral ...
Lakshay Khurana +3 more
doaj +1 more source