Hearing restoration by gene replacement therapy for a multisite-expressed gene in a mouse model of human DFNB111 deafness. [PDF]
Am J Hum GenetGene therapy has made significant progress in the treatment of hereditary hearing loss. However, most research has focused on deafness-related genes that are primarily expressed in hair cells with less attention given to multisite-expressed deafness ...
Jiang L +12 more
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Analyzing efficacy, stability, and safety of AAV-mediated optogenetic hearing restoration in mice. [PDF]
Life Sci Alliance, 2022 This longitudinal study revealed stable expression of the fast-gating channelrhodopsin f-Chrimson in cochlear neurons of mice over at least 2 yr upon a single postnatal AAV dosing of the cochlea.
Bali B +4 more
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Auditory Brainstem Implants-Hearing Restoration in Congenitally Deaf Children. [PDF]
Dtsch Arztebl Int, 2022 BACKGROUND Children who are born deaf can learn to hear and to speak with the aid of a cochlear implant (CI). If the implantation of a CI is not possible for anatomical reasons, an auditory brainstem implant (ABI) is the only surgical option for auditory
Behr R, Schwager K, Hofmann E.
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Graded optogenetic activation of the auditory pathway for hearing restoration.
Brain Stimul, 2023 Optogenetic control of neural activity enables innovative approaches to improve functional restoration of diseased sensory and motor systems. For clinical translation to succeed, optogenetic stimulation needs to closely match the coding properties of the
Mittring A, Moser T, Huet AT.
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Resilience and vulnerability of neural speech tracking after hearing restoration. [PDF]
Commun BiolThe role of early auditory experience in the development of neural speech tracking remains an open question. To address this issue, we measured neural speech tracking in children with or without functional hearing during their first year of life after ...
Federici A +12 more
europepmc +2 more sources
Artificial intelligence-enabled innovations in cochlear implant technology: Advancing auditory prosthetics for hearing restoration. [PDF]
Bioeng Transl MedThis comprehensive review explores the implications of artificial intelligence (AI) in addressing cochlear implant (CI) issues and revolutionizing the landscape of auditory prosthetics.
Zhang G +7 more
europepmc +2 more sources
Bridging Neurobiology and Artificial Intelligence: A Narrative Review of Reviews on Advances in Cochlear and Auditory Neuroprostheses for Hearing Restoration. [PDF]
Biology (Basel)Simple Summary Hearing loss involves complex biological damage to sensory and neural components of the auditory system. Auditory neuroprosthetics aim to restore function by directly interfacing with these neural pathways.
Giansanti D.
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Hearing restoration through hair cell regeneration: A review of recent advancements and current limitations. [PDF]
Hear ResHearing loss is extremely common, yet limited treatment options are available to restore hearing, and those that are available provide incomplete recovery of hearing detection.
McGovern MM, Cox BC.
europepmc +2 more sources
Stem cell-based approaches: Possible route to hearing restoration? [PDF]
World J Stem Cells, 2020 Disabling hearing loss is the most common sensorineural disability worldwide. It affects around 466 million people and its incidence is expected to rise to around 900 million people by 2050, according to World Health Organization estimates. Most cases of
Durán-Alonso MB.
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ORL J Otorhinolaryngol Relat Spec, 2021 Background/Aims: This study was conducted to evaluate the long-term stability of fat-graft myringoplasty (FGM) for chronic tympanic membrane perforations, analyzing the perforation closure rate and re-gained hearing outcome with respect to the size and ...
Han JS +4 more
europepmc +2 more sources