Results 81 to 90 of about 226,686 (358)

Cryopreserved Human Otic Neuronal Spheroids Self‐assemble for Functional Connectivity Analysis and Long‐term Ototoxicity Evaluation

Advanced Science, EarlyView.
This study establishes a robust and reproducible protocol for generating human otic neuronal spheroids (hONS) from cryopreserved hPSC‐derived pre‐placodal ectoderm cells. These hONS further differentiate into functional SGN‐like neurons, which extend neurite projections toward both murine hair cells and human cortical organoids, thereby forming ...
Gaoying Sun, Yukai Wang, Man Wang, Xinyue Wang, Mingming Tang, Da Li, Jianhuan Qi, Xue Wang, Shujuan Sun, Lei Chen, Weibin An, Ligang Kong, Anqi Suo, Haibo Wang, Wenwen Liu, Lei Xu   +15 more
wiley   +1 more source

Reciprocal anatomical relationship between primary sensory and prefrontal cortices in the human brain [PDF]

, 2011
The human brain exhibits remarkable interindividual variability in cortical architecture. Despite extensive evidence for the behavioral consequences of such anatomical variability in individual cortical regions, it is unclear whether and how different ...
Kanai, Ryota, Rees, Geraint, Schwarzkopf, Dietrich Samuel, Song, Chen   +3 more
core   +2 more sources

Contrast Tuning in Auditory Cortex [PDF]

Science, 2003
The acoustic features useful for converting auditory information into perceived objects are poorly understood. Although auditory cortex neurons have been described as being narrowly tuned and preferentially responsive to narrowband signals, naturally occurring sounds are generally wideband with unique spectral energy profiles.
Dennis L, Barbour, Xiaoqin, Wang
openaire   +2 more sources

Deciphering Neural Mechanisms Underlying Marmoset Dynamic Natural Behaviors Using a Miniaturized Wireless Large‐Scale Coverage Neural Recorder

Advanced Science, EarlyView.
This study introduces a miniaturized wireless neural recording system integrated with custom‐designed 120‐channel µECoG arrays, engineered for monitoring brain activities in freely behaving marmosets. The system can capture and characterize behavior‐specific neural signals, including drinking‐related activation, pre‐vocalization anticipatory responses,
Hongru Liu, Xinyuan Cao, Jiyong Li, Lingyi Zheng, Jingwei Li, Qianbing Li, Min Xie, Huimin Li, Xiaolong Wang, Yuyu Wu, Xiangyu Zhang, Yizheng Wang, Xize Gao, Tiancheng Sheng, Nianzhen Du, Chengao Xu, Kai Zhou, Jing Xu, Changxiang Yan, Lianqing Liu, Lixia Gao, Xinjian Li, Mingjun Zhang   +22 more
wiley   +1 more source

Visual activation of auditory cortex reflects maladaptive plasticity in cochlear implant users [PDF]

, 2017
Cross-modal reorganization in the auditory cortex has been reported in deaf individuals. However, it is not well understood whether this compensatory reorganization induced by auditory deprivation recedes once the sensation of hearing is partially ...
Debener, Stefan, Dillier, Norbert, Eichele, Tom, Jäncke, Lutz, Kegel, Andrea, Marcar, Valentine Leslie, Meyer, Martin, Pascual-Marqui, Roberto Domingo, Sandmann, Pascale   +8 more
core  

NADPH Oxidase 2-Mediated Insult in the Auditory Cortex of Zucker Diabetic Fatty Rats

Neural Plasticity, 2019
Clinical data has confirmed that auditory impairment may be a secondary symptom of type 2 diabetes mellitus (T2DM). However, mechanisms underlying pathologic changes that occur in the auditory system, especially in the central auditory system (CAS ...
Zheng-De Du, Wei Wei, Shukui Yu, Qing-Ling Song, Ke Liu, Shu-Sheng Gong   +5 more
doaj   +1 more source

Multimodal Imaging Reveals Cerebral Microcirculation Dynamics and Mechanisms in Mouse Central Nervous System After Intranasal Infection With Recombinant Pseudorabies Virus

Advanced Science, EarlyView.
Multi‐modality imaging strategy applied to PRV‐induced central nervous system infection enables dynamic visualization of cerebrovascular dysfunction, including hyperemia, hypoperfusion, and vascular remodeling. These changes are linked to microglial activation and impaired angiogenesis, providing mechanistic insight into PRV neuropathogenesis and ...
Shuting Ling, Chongxin Wu, Mengxuan Gui, Kaiyun Chen, Yanbo Yang, Jiwei Xing, Fengxian Du, Wei Liao, Luyao Yang, Zhaokui Jin, Ningshao Xia, Guosong Wang, Yixin Chen, Qingliang Zhao   +13 more
wiley   +1 more source

The auditory cortex hosts network nodes influential for emotion processing: An fMRI study on music-evoked fear and joy. [PDF]

PLoS ONE, 2018
Sound is a potent elicitor of emotions. Auditory core, belt and parabelt regions have anatomical connections to a large array of limbic and paralimbic structures which are involved in the generation of affective activity.
Stefan Koelsch, Stavros Skouras, Gabriele Lohmann   +2 more
doaj   +1 more source

Exploration of Novel Biomarkers Through a Precision Medicine Approach Using Multi‐Omics and Brain Organoids in Patients With Atypical Depression and Psychotic Symptoms

Advanced Science, EarlyView.
This study examines major depressive disorder with atypical features and psychotic symptoms through a multi‐omics precision medicine approach. By integrating clinical assessments, WBC scRNA‐seq, plasma proteomics, and brain organoid models, it uncovers immune dysregulation, synaptic protein alterations, and stress‐sensitive neuronal changes.
Insook Ahn, Soyeon Chang, Jiyoung Lee, Seok‐Ho Choi, Jinju Han, Yangsik Kim   +5 more
wiley   +1 more source

Mismatch negativity in recent-onset and chronic schizophrenia: a current source density analysis. [PDF]

PLoS ONE, 2014
Mismatch negativity (MMN) is a component of the event-related potential elicited by deviant auditory stimuli. It is presumed to index pre-attentive monitoring of changes in the auditory environment.
W Ross Fulham, Patricia T Michie, Philip B Ward, Paul E Rasser, Juanita Todd, Patrick J Johnston, Paul M Thompson, Ulrich Schall   +7 more
doaj   +1 more source