Maturation of NaV and KV channel topographies in the auditory nerve spike initiator before and after developmental onset of hearing function [PDF]
Journal of Neuroscience, 2016 Auditory nerve excitation and thus hearing depend on spike-generating ion channels and their placement along the axons of auditory nerve fibers (ANFs).
Kim, Kyunghee X, Rutherford, Mark A
core +3 more sources
Age-related changes of myelin basic protein in mouse and human auditory nerve. [PDF]
PLoS ONE, 2012 Age-related hearing loss (presbyacusis) is the most common type of hearing impairment. One of the most consistent pathological changes seen in presbyacusis is the loss of spiral ganglion neurons (SGNs).
Yazhi Xing +5 more
doaj +2 more sources
Sensory overamplification in layer 5 auditory corticofugal projection neurons following cochlear nerve synaptic damage [PDF]
Nature Communications, 2018 Layer 5 (L5) cortical projection neurons innervate far-ranging brain areas to coordinate integrative sensory processing and adaptive behaviors. Here, we characterize a plasticity in L5 auditory cortex (ACtx) neurons that innervate the inferior colliculus
Meenakshi M. Asokan +3 more
openalex +2 more sources
A point process framework for modeling electrical stimulation of the auditory nerve [PDF]
Journal of Neurophysiology, 2012 Model-based studies of auditory nerve responses to electrical stimulation can provide insight into the functioning of cochlear implants. Ideally, these studies can identify limitations in sound processing strategies and lead to improved methods for ...
Brill S +13 more
core +2 more sources
Temporal Coding of Single Auditory Nerve Fibers Is Not Degraded in Aging Gerbils [PDF]
Journal of Neuroscience, 2019 People suffering from age-related hearing loss typically present with deficits in temporal processing tasks. Temporal processing deficits have also been shown in single-unit studies at the level of the auditory brainstem, midbrain, and cortex of aged ...
Amarins N. Heeringa +5 more
openalex +2 more sources
Auditory-nerve responses in mice with noise-induced cochlear synaptopathy.
J Neurophysiol, 2021 Cochlear synaptopathy is the noise-induced or age-related loss of ribbon synapses between inner hair cells (IHCs) and auditory nerve fibers (ANFs), first reported in CBA/CaJ mice.
Suthakar K, Liberman MC.
europepmc +2 more sources
μLED‐based optical cochlear implants for spectrally selective activation of the auditory nerve
EMBO Molecular Medicine, 2020 Electrical cochlear implants (eCIs) partially restore hearing and enable speech comprehension to more than half a million users, thereby re‐connecting deaf patients to the auditory scene surrounding them.
A. Dieter +10 more
semanticscholar +1 more source
Auditory cortex basal activity modulates cochlear responses in chinchillas. [PDF]
PLoS ONE, 2012 BACKGROUND: The auditory efferent system has unique neuroanatomical pathways that connect the cerebral cortex with sensory receptor cells. Pyramidal neurons located in layers V and VI of the primary auditory cortex constitute descending projections to ...
Alex León +4 more
doaj +1 more source
Cochlear Implantation Outcomes in Patients With OTOF Mutations
Frontiers in Neuroscience, 2020 Auditory neuropathy is a special type of hearing loss caused by dysfunction of the synapse of the inner hair cells, the auditory nerve, and/or the auditory nerve itself.
Dandan Zheng, Xiao Liu
doaj +1 more source
Differential roles for EphA and EphB signaling in segregation and patterning of central vestibulocochlear nerve projections. [PDF]
PLoS ONE, 2013 Auditory and vestibular afferents enter the brainstem through the VIIIth cranial nerve and find targets in distinct brain regions. We previously reported that the axon guidance molecules EphA4 and EphB2 have largely complementary expression patterns in ...
Michelle R Allen-Sharpley +2 more
doaj +1 more source