Results 81 to 90 of about 58,385 (334)

The Yin and Yang of Auditory Nerve Damage [PDF]

open access: yesNeuron, 2016
Chambers et al. investigate consequences in the central auditory system after profound cochlear denervation. They observed gains in firing rate in auditory cortex despite nearly absent auditory nerve and brainstem responses, suggesting an important role of central plasticity and its clinical implications.
openaire   +3 more sources

Frequency decoding of periodically timed action potentials through distinct activity patterns in a random neural network [PDF]

open access: yes, 2012
Frequency discrimination is a fundamental task of the auditory system. The mammalian inner ear, or cochlea, provides a place code in which different frequencies are detected at different spatial locations. However, a temporal code based on spike timing is also available: action potentials evoked in an auditory-nerve fiber by a low-frequency tone occur ...
arxiv   +1 more source

Programmable NIR Responsive Nanocomposite Enables Noninvasive Intratympanic Delivery of Dexamethasone to Reverse Cisplatin Induced Hearing Loss

open access: yesAdvanced Science, EarlyView.
In this study, saponin‐coated silica@gold nanocarriers responsive to NIR radiation is developed to enhance intratympanic drug delivery for cisplatin‐induced hearing loss (CIHL) treatment. The biocompatibility and oto‐protective properties are validated both in vitro and in vivo.
Rawand A. Mustafa   +6 more
wiley   +1 more source

Processing efficiency in pediatric cancer survivors: A review and operationalization for outcomes research and clinical utility

open access: yesBrain and Behavior, Volume 12, Issue 12, December 2022., 2022
Abstract Objective Childhood cancer and cancer‐related treatments disrupt brain development and maturation, placing survivors at risk for cognitive late effects. Given that assessment tools vary widely across researchers and clinicians, it has been daunting to identify distinct patterns in outcomes across diverse cancer types and to implement ...
Julie A. Trapani, Donna L. Murdaugh
wiley   +1 more source

Single Administration of AAV‐mAtp6v1b2 Gene Therapy Rescues Hearing and Vestibular Disorders Caused by Atp6v1b2‐Induced Lysosomal Dysfunction in Hair Cells

open access: yesAdvanced Science, EarlyView.
Wei et al. establish a hair cell‐specific conditional knockout mouse model (Atp6v1b2fl/fl;Atoh1Cre/+), and demonstrate the importance of Atp6v1b2 for hair cell through maintaining the survival of lysosomes. A single administration of AAV‐ie‐Eh3‐mAtp6v1b2 through scala media at P0‐P2 realizes function compensation and restores hearing and balance ...
Gege Wei   +15 more
wiley   +1 more source

Blockchain technologies as enablers of supply chain mapping for sustainable supply chains

open access: yesBusiness Strategy and the Environment, Volume 31, Issue 8, Page 3742-3756, December 2022., 2022
Abstract The advent of blockchain technologies is transmuting the way conventional supply chains are being managed. Due to the complexity of dealing with many actors involved in the supply chain networks, contemporary supply chains have limited visibility, transparency, and accountability.
Sharfuddin Ahmed Khan   +5 more
wiley   +1 more source

Consequences and Mechanisms of Noise‐Induced Cochlear Synaptopathy and Hidden Hearing Loss, With Focuses on Signal Perception in Noise and Temporal Processing

open access: yesAdvanced Science, EarlyView.
Noise‐induced synaptopathy (NIS) is largely reversible due to self‐repair. NIS and noise‐induced hidden hearing loss are two concepts with similarities and differences. The major hearing deficits in NIHHL are temporal processing disorders. The translation of animal data in NIS studies to humans is hindered by many factors.
Hui Wang, Steven J Aiken, Jian Wang
wiley   +1 more source

Ninjinyoeito Has a Protective Effect on the Auditory Nerve and Suppresses the Progression of Age-Related Hearing Loss in Mice

open access: yesFrontiers in Nutrition, 2020
Currently, there are limited reports available regarding the treatment and prevention of progressive age-related hearing loss. This is because age-related hearing loss is not a critical disease with direct fatalities and has several well-established ...
Takanori Kawashima   +3 more
doaj   +1 more source

On the precision of neural computation with interaural time differences in the medial superior olive [PDF]

open access: yesarXiv, 2020
Incoming sound is in cochlea and auditory nerve encoded into spike trains. At the third neuron of the auditory pathway, spike trains of the left and right sides are processed in brainstem nuclei to yield sound localization information. Two different localization encoding mechanisms are employed in two centers for low and high sound frequencies in the ...
arxiv  

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