Results 131 to 140 of about 23,141,464 (287)
Neural Response Reliability as a Marker of the Transition of Neural Codes along Auditory Pathways
Advanced Science, EarlyView.Decoding sound from neural activity in mice reveals a striking shift in how the brain encodes sound: from precise but redundant timing codes in early auditory areas to efficient, synergistic rate‐based codes in the cortex. This transformation highlights a robust neural strategy for turning complex acoustic input into coherent perception across the ...
Alexa Buck +7 more
wiley +1 more source
Auditory Reserve and the Legacy of Auditory Experience
Brain Sciences, 2014 Musical training during childhood has been linked to more robust encoding of sound later in life. We take this as evidence for an auditory reserve: a mechanism by which individuals capitalize on earlier life experiences to promote auditory processing. We
Erika Skoe, Nina Kraus
doaj +1 more source
ARSTREAM: A Neural Network Model of Auditory Scene Analysis and Source Segregation [PDF]
, 1997 Multiple sound sources often contain harmonics that overlap and may be degraded by environmental noise. The auditory system is capable of teasing apart these sources into distinct mental objects, or streams.
Grossberg, Stephen +3 more
core
Journal of Neuroscience, 2011 Neural activity in the auditory system decreases with repeated stimulation, matching stimulus probability in multiple timescales. This phenomenon, known as stimulus-specific adaptation, is interpreted as a neural mechanism of regularity encoding aiding ...
Jordi Costa-Faidella +3 more
semanticscholar +1 more source
Advanced Science, EarlyView.CDGSH iron sulfur domain 1 (CISD1) mitigates oxidative stress by promoting NADH oxidation and Coenzyme Q (CoQ) reduction. Under chronic stress, elevated CISD1 expression in microglia enhances NAD⁺ production, thereby increasing GAPDH activity and glycolytic flux, while reducing ATP synthesis by inhibiting proton transfer from mitochondrial complexes I ...
Wanting Dong +5 more
wiley +1 more source
Wearable Hearing Assist System to Provide Hearing-Dog Functionality
Robotics, 2019 This study developed a wearable hearing-assist system that can identify the direction of a sound source while using short-term interaural time differences (ITDs) of sound pressure and convey the sound source direction to a hearing-impaired person via ...
Ryuichi Shimoyama
doaj +1 more source
Advanced Science, EarlyView.The preferred derivative JX3212 demonstrates strong inhibitory activity against Kir4.1 with favorable druggability and shows significant antidepressant efficacy in vivo. Abstract Major depressive disorder is a serious psychiatric disorder for which novel and fast‐acting antidepressants are required.
Sisi Wang +15 more
wiley +1 more source
Advanced Science, EarlyView.This study establishes a mandibular asymmetry (MA) mouse model that recapitulates chronic orofacial pain and anxiety comorbidity. Anterior cingulate cortex (ACC) hyperactivation and synaptic dysfunction are identified as central neural mechanisms underlying these pathologies, with chemogenetic inhibition of ACC CaMKII+ neurons effectively reversing ...
Zhaoyichun Zhang +19 more
wiley +1 more source
The Geometry of Layer 2/3 Cortical Sound Processing in Slow Wave Sleep
Advanced Science, EarlyView.Sleep is associated with a sensory disconnection whose mechanisms remain elusive. Large neuronal population recordings in the auditory cortex revealed that, in NREM sleep, the neural code for sounds is highly similar to wakefulness, but coordinated modulations of neuron responsiveness intermittently disconnect the local cortical networks from sensory ...
Allan Muller +3 more
wiley +1 more source
Astrocytic PERK Deficiency Drives Prefrontal Circuit Dysfunction and Depressive‐Like Behaviors
Advanced Science, EarlyView.Chen et al. show that the endoplasmic reticulum (ER) stress sensor PERK is downregulated in prefrontal cortex (PFC) astrocytes in major depressive disorder and in chronic‐stress mouse models. In young mice, astrocyte‐specific PERK loss reduces the synaptogenic cue thrombospondin‐1 (TSP1), leading to synaptic and circuit deficits and depressive‐like ...
Kai Chen +8 more
wiley +1 more source