Results 131 to 140 of about 17,455,516 (298)

MethyAnno: An Interpretable Automated Annotation Method Leveraging Multi‐Scale Information and Metric Learning Framework for scDNAm Data

open access: yesAdvanced Science, EarlyView.
MethyAnno enables robust and interpretable annotation of single‐cell DNA methylation data by integrating multi‐scale epigenetic information, bidirectional cross‐attention, and prototype‐based metric learning. The framework resolves rare and novel cell types across datasets while revealing cell‐type‐specific epigenetic signatures associated with disease
Yuhang Jia   +4 more
wiley   +1 more source

Review of aspects of auditory signal studies in Japan

open access: yes, 2002
Presented at the 8th International Conference on Auditory Display (ICAD), Kyoto, Japan, July 2-5, 2002.Presented at the 8th International Conference on Auditory Display (ICAD), Kyoto, Japan, July 2-5, 2002.Sound is very important in human communication ...
Tsuchida, Y.
core  

TECTB Variants Reveal Tectorial Membrane Vulnerability in Dominant Non‐Syndromic Hearing Loss

open access: yesAdvanced Science, EarlyView.
TECTB is a non‐collagenous protein of the tectorial membrane – an extracellular matrix of the cochlea. This study identifies dominant missense variants in TECTB linked to human hereditary deafness in two unrelated families. Genetically engineered mice homozygous for one of the variants are profoundly deaf, whereas heterozygous mice have normal hearing ...
Evan B. Hale   +23 more
wiley   +1 more source

Transient Sleep Deprivation Induces Persistent Auditory Neuropathy via ROS‐Initiated Neuroinflammation and BK Channel Suppression

open access: yesAdvanced Science, EarlyView.
Sleep disturbance severity closely tracks hearing loss in a clinical cohort, yet the mechanistic link remains unclear. Acute sleep deprivation is shown to trigger transient cochlear oxidative stress that switches into a self‐sustaining neuroinflammatory state, suppressing BK channels and causing irreversible synaptopathy.
Dan Chen   +11 more
wiley   +1 more source

Auditory cues determining the perception of the size and speed of rolling balls

open access: yes, 2001
Presented at the 7th International Conference on Auditory Display (ICAD), Espoo, Finland, July 29-August 1, 2001.Presented at the 7th International Conference on Auditory Display (ICAD), Espoo, Finland, July 29-August 1, 2001.This study investigates the ...
Kohlrausch, Armin   +2 more
core   +1 more source

TGFBI Maintains Fibrocartilage Homeostasis by Restraining O‐GlcNAcylation to Inactivate and Destabilize ADAMTS16 in Temporomandibular Joint Osteoarthritis

open access: yesAdvanced Science, EarlyView.
TGFBI deficiency elevates O‐GlcNAcylation, promoting the transcriptional activation of ADAMTS16 and OGT‐mediated post‐translational modification of ADAMTS16 at Ser1170. This leads to its stabilization and accumulation, driving chondrocyte metabolic disorders and senescent phenotypes, ultimately resulting in fibrocartilage dysfunction and TMJOA ...
Xin Liu   +12 more
wiley   +1 more source

Abstract Representation of Movement Parameters in Basal Ganglia Output

open access: yesAdvanced Science, EarlyView.
The basal ganglia output provides a scalable velocity/position signal across behavioral contexts, supporting the idea that these variables are represented in the brain as abstract entities rather than as fixed changes in joint angles or specific sets of body effectors.
Ana Silvia Báez‐Cordero   +3 more
wiley   +1 more source

Spatially-modulated auditory alerts

open access: yes, 2003
Proceedings of the 9th International Conference on Auditory Display (ICAD), Boston, MA, July 7-9, 2003.Presented at the 9th International Conference on Auditory Display (ICAD), Boston, MA, July 7-9, 2003.The technique of spatial modulating (``jittering'')
Anderson, Mark R   +2 more
core  

Editorial: Spontaneous Activity in Sensory Systems

open access: yesFrontiers in Neural Circuits, 2018
Kazuo Imaizumi   +3 more
doaj   +1 more source

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