Results 51 to 60 of about 73,000 (259)
Augmentation index in patients with different stages of hypertension
Кардиоваскулярная терапия и профилактика, 2020 Aim. To assess the augmentation index (AIx) in hypertensive patients depending on stages of hypertension (HTN).Material and methods. Eighty-three people were examined: 62 patients with HTN and 21 patients of the control group.
V. I. Podzolkov +3 more
doaj +1 more source
Arterial Stiffness in Patients with Sarcoidosis and Obstructive Sleep Apnea
Journal of Vascular Diseases, 2023 Background: Obstructive sleep apnea (OSA) and sarcoidosis have both been implied to be risk factors for increased arterial stiffness. However, it is unclear whether an elevated apnea–hypopnea index (AHI) in sarcoidosis patients increases arterial ...
Maurice Roeder +5 more
doaj +1 more source
Increased augmentation index in patients with cystic fibrosis [PDF]
European Respiratory Journal, 2009 Increased large artery stiffness occurs in a range of inflammatory conditions indicating an ageing of the vasculature and additionally being an independent risk factor for cardiovascular events. We determined large artery parameters in adults with cystic fibrosis (CF).
J H, Hull +6 more
openaire +2 more sources
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Diagnostics, 2023 The increased cardiovascular (CV) risk among patients with autoimmune rheumatic diseases, such as arthritides and connective tissue diseases, has been extensively documented.
Konstantinos Triantafyllias +5 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Evaluation of arterial stiffness in cardiac surgical patients using applanation tonometry
Annals of Cardiac Anaesthesia, 2020 Context: Applanation tonometry enables the noninvasive analysis of arterial pressure wave morphology. Applanation tonometry provides the augmentation index (AIx, %), an index of arterial stiffness that partially reflects arterial-ventricular (A-V ...
Federico Franchi +7 more
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Modern methods for assessing cardiovascular risk in hypertension [PDF]
Ķazaķstannyṇ Klinikalyķ Medicinasy, 2016 Arterial hypertension is one of the most common diseases of the cardiovascular system, and is a leading risk factor for sudden death, both in Kazakhstan and abroad.
Gulnur Kerimkulova, Gulnar Zhussupova
doaj +1 more source