Results 61 to 70 of about 73,000 (259)

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

Pulse wave velocity and carotid atherosclerosis in White and Latino patients with hypertension

BMC Cardiovascular Disorders, 2011
Background Preventive cardiology has expanded beyond coronary heart disease towards prevention of a broader spectrum of cardiovascular diseases. Ethnic minorities are at proportionately greater risk for developing extracoronary vascular disease including
Karimkahani Elhum, Hosokawa Patrick, Long Carlin S, Krantz Mori J, Dickinson Miriam, Estacio Raymond O, Masoudi Frederick A, Havranek Edward P   +7 more
doaj   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Peripheral “Oscillatory” Compliance Is Associated With Aortic Augmentation Index [PDF]

Hypertension, 2001
Abstract —The augmentation index (AIx) and “oscillatory” compliance (C 2 ) are wave contour analysis parameters for the central aorta (P ao ) and radial artery pressure wave (P rad ), respectively.
Segers, P, Qasem, A, De Backer, T, Carlier, S, Verdonck, P, Avolio, A   +5 more
openaire   +3 more sources

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source

Influence of Fixed Combination of Metformin SR and Glimepiride on Carbohydrate, Lipid Metabolism and Arterial Wall Stiffness in Patients with Diabetes Mellitus Type 2

Mìžnarodnij Endokrinologìčnij Žurnal, 2015
To study the effect of hypoglycemic therapy with combination of glimepiride and metformin SR during 12 weeks on carbohydrate and lipid metabolism parameters, changes in the adipokines level in blood plasma and parameters of arterial wall stiffness of ...
O.S. Larin, K.O. Zuiev, D.H. Kohut
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

CENTRAL AORTIC PRESSURE AND CARDIOVASCULAR RISK FACTORS ASSESSMENT IN STUDENTS AS A PART OF THE YOUTH SCREENING IMPROVEMENT

Российский кардиологический журнал, 2015
Aim. To study the main risk factors on representative group of first-year students of StSMU during their screening, and on pilot group of students to study possible ways of influencing on these factors on CBP and its augmentation index.Material and ...
M. E. Evsevyeva, M. V. Eryomin, M. V. Rostovtseva, O. V. Sergeeva   +3 more
doaj   +1 more source

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

Central aortic pressure parameters in patients with ischemic chronic heart failure

Российский кардиологический журнал, 2013
Aim. To evaluate the parameters of central aortic pressure in patients with chronic heart failure (CHF) of ischemic aetiology. Material and methods. The study included 89 patients with ischemic CHF, aged from 41 to 73 years (mean age 56,1±0,8 years), and
T. Kh. Temirsultanova, O. V. Ilukhin, Yu. M. Lopatin   +2 more
doaj   +1 more source