Results 41 to 50 of about 2,158,008 (249)

Serum Myonectin Levels Are Positively Associated With Physical Function and Lower Frailty‐Related Limitation in Maintenance Hemodialysis Patients: A Cross‐Sectional Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Maintenance hemodialysis (MHD) patients frequently suffer from frailty, characterized by reduced physical function and poor prognosis. Myokines, such as myonectin, secreted by muscle, are emerging regulators of systemic health. This study investigated the relationship between serum myonectin, adipokines (adiponectin, omentin), and ...
Kenichi Kono, Yoshifumi Moriyama, Koji Ohashi, Naoya Otaka, Minako Tatsumi, Toyoaki Murohara, Noriyuki Ouchi, Satoru Oshima   +7 more
wiley   +1 more source

Sustained high expression of human FVII following AAV8-mediated gene delivery in mice

Molecular Therapy: Methods & Clinical Development
Factor VII (FVII) deficiency is a rare bleeding disorder with a prevalence of approximately 1:300,000–500,000 individuals. We explored whether adeno-associated virus (AAV)-mediated gene therapy can achieve durable and functional expression of human FVII (
Andrea D’Amico, Bas Blits, Joëlle van den Herik, Fred de Winter, Paul H.P. Kaijen, Barbara Hobo, Alexander Henrik van Asbeck, Joost Verhaagen, David G.M. Mosmuller, Jan Voorberg   +9 more
doaj   +1 more source

The effects of weekly augmentation therapy in patients with PiZZ α1-antitrypsin deficiency

, 2012
ST Schmid,1 J Koepke,1 M Dresel,1 A Hattesohl,1 E Frenzel,2 J Perez,3 DA Lomas,4 E Miranda,5 T Greulich,1 S Noeske,1 M Wencker,6 H Teschler,6 C Vogelmeier,1 S Janciauskiene,2,* AR Koczulla1,*1Department of Internal Medicine, Division for Pulmonary ...
Janciauskiene S, Dresel M, A. Hattesohl, Rembert Koczulla, J. Koepke, Wencker M, M. Dresel, J. Perez, Noeske S, Vogelmeier C, MIRANDA BANOS, MARIA ELENA, Teschler H, Perez J, T. Greulich, S. T. Schmid, H. Teschler, E. Frenzel, M. Wencker, Koczulla AR, S. Janciauskiene, C. Vogelmeier, Koepke J, Schmid ST, D. A. Lomas, Greulich T, Lomas DA, Frenzel E, Hattesohl A, S. Noeske, Miranda E   +29 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Cost Comparison of Suture Anchor Modified Broström Repair and Augmentation of the Modified Broström with FiberTape Device

Foot & Ankle Orthopaedics, 2020
Category: Ankle; Sports Introduction/Purpose: Augmentation of the Broström procedure with FiberTape device has been described for the treatment of chronic ankle instability.
Emily Vannatta BS, Chris M. Stauch, Jesse King BSc, Morgan S. Kim, Laura R. Luick, Shawn M. Bifano MD, Paul J. Juliano MD, Umur Aydogan MD, Michael C. Aynardi MD   +8 more
doaj   +1 more source

Treatment planning study comparing proton therapy, RapidArc and intensity modulated radiation therapy for a synchronous bilateral lung cancer case

, 2014
Purpose: The main purpose of this study is to perform a treatment planning study on a synchronous bilateral non-small cell lung cancer case using three treatment modalities: uniform scanning proton therapy, RapidArc, and intensity modulated radiation ...
Zheng, Yuanshui; Department of Medical Physics, ProCure Proton Therapy Center, Oklahoma City, OK, USA., Zhao, Li; Department of Medical Physics, ProCure Proton Therapy Center, Oklahoma City, OK, USA., Risalvato, Dina; Department of Medical Dosimetry, ProCure Proton Therapy Center, Oklahoma City, Oklahoma, USA., Vargas, Carlos; Radiation Oncology, Proton Collaborative Group (PCG), Bloomington, Indiana, USA., Rana, Suresh; Department of Medical Physics, ProCure Proton Therapy Center, Oklahoma City, OK, USA., Pokharel, Shyam; Department of Medical Physics, 21st Century Oncology, Fort Myers, Florida, USA., Cersonsky, Nancy; Department of Radiation Oncology, ProCure Proton Therapy Center, Oklahoma City, Oklahoma, USA.   +6 more
core   +1 more source

data augmentation for chromosomes classification [PDF]

, 2023
openUtilizzo di diversi tipi di data augmentation per ottenere migliori prestazioni durante la classificazione di cromosomi con rete ...
GUGLIELMO, NICOLAS
core  

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Phenotypic Expression of Respiratory Diseases and Tailored Treatment in Patients with Intermediate Alpha-1 Antitrypsin Deficiency: Evidence from a Retrospective Analysis of a Selected Cohort of Patients

Medicina
Introduction: Alpha-1 antitrypsin deficiency (AATD) is a genetic condition caused by SERPINA1 variants with variable severity. Current international guidelines do not recommend augmentation therapy for intermediate AATD; nevertheless, some patients show ...
Anna Annunziata, Giuseppe Fiorentino, Francesca Simioli, Lidia Atripaldi, Marco Balestrino, Giacomo Zuccarini, Barbara Piras, Alessandro Libra, Fabio Pino, Pierpaolo Di Micco, Carmine Siniscalchi, Ilaria Ferrarotti, Luigi Aronne, Raffaella Manzo, Carlo Vancheri, Cecilia Calabrese   +15 more
doaj   +1 more source

Vacancy Augmented Piezo‐Sonosensitizer for Cancer Therapy

Advanced Science, 2023
AbstractSonodynamic therapy (SDT) has been widely reported as a noninvasive and high‐penetration therapy for cancer; however, the design of an efficient sonosensitizer remains an urgent need. To address this issue, molybdenum disulfide nanoflowers (MoS2 NF) as piezo‐sonosensitizers and introduced sulfur vacancies on the MoS2 NF (Sv‐MoS2 NF) to improve ...
Qingyuan Wu, Jie Zhang, Xueting Pan, Zhijun Huang, Haoyuan Zhang, Juan Guo, Yun Xue, Rui Shi, Huiyu Liu   +8 more
openaire   +3 more sources