Results 71 to 80 of about 2,655,766 (243)

Integrated PANoptosis Profiling Identifies Immunosuppressive Subtypes and a Prognostic Signature With Functional Validation of MLKL in Glioblastoma

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The prognosis of glioblastoma (GBM) remains highly unfavorable, largely due to high tumor heterogeneity and an immunosuppressive microenvironment. However, the functional role of PANoptosis in this context is poorly understood. Methods Patients were stratified via K‐means clustering. A risk score model was constructed using prognosis‐
Langfei Tian, Minghui Zhao, Yuanbo Hu, Kaiyue Wang, Haiguang Liu, Zetong Bai, Kebin Zheng   +6 more
wiley   +1 more source

Memantine as an Augmentation Therapy for Anxiety Disorders

Case Reports in Psychiatry, 2012
Objective. Glutamate, an excitatory neurotransmitter in the central nervous system (CNS), may play a role in the development of anxiety. Memantine partially blocks N-methyl-D-aspartate (NMDA) receptors' glutamate channels located in the CNS.
Thomas L. Schwartz, Umar A. Siddiqui, Shafi Raza   +2 more
doaj   +1 more source

Intervertebral Disc Repair: Current Concepts

Global Spine Journal, 2020
Study Design: Review article. Objective: A review of the literature on current strategies utilized in intervertebral regeneration and repair efforts. Methods: A review of the literature and analysis of the data to provide an updated review on current ...
Derek G. Ju MD, Linda E. Kanim MA, Hyun W. Bae MD   +2 more
doaj   +1 more source

Augmenting and Assaying Nav1.1 Protein Quantity for Dravet Syndrome Therapy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Dravet Syndrome (DS) is a developmental and epileptic encephalopathy predominantly caused by heterozygous loss‐of‐function variants in SCN1A, which encodes Nav1.1. Conserved upstream open reading frames (uORFs) in SCN1A were validated to regulate translation in reporter assays, demonstrating the therapeutic viability of increasing Nav1.1 from ...
Aiswarya Saravanan, Jordan Safran, Anna Loughman, Grace Lin, Shivanshi Vaid, Dana Allababidi, Peter M. Tessier, Louis T. Dang   +7 more
wiley   +1 more source

Healthcare Costs For Patients With Severe Alpha-1 Antitrypsin Deficiency Among Augmentation Therapy Users And Non-Users And Impact Of Therapy Frequency [PDF]

, 2023
Background: Alpha-1 antitrypsin deficiency (AATD) is a rare disease caused by a genetic mutation in the SERPINA1 gene which causes low levels of or no working alpha-1 antitrypsin protein to be made.
Raina, Nikita
core   +1 more source

Ridge Preservation and Augmentation Using a Carbonated Apatite Bone Graft Substitute: A Case Series

Dentistry Journal
The newly developed mineral carbonated apatite has recently been proposed as a bone graft material for bone regenerative treatment in implant therapy.
Yoichi Taniguchi, Tatsuro Koyanagi, Toru Takagi, Yutaro Kitanaka, Akira Aoki, Takanori Iwata   +5 more
doaj   +1 more source

Early-term Aripiprazole Augmentation and Clinical Efficacy in Treatment of Pediatric OCD: A Case Series of Six Adolescents

Psychiatry and Behavioral Sciences, 2019
Obsessive- compulsive disorder (OCD) in childhood is characterized by intrusive thoughts and compulsions causing significant levels of distress and functional deterioration.
Ferhat Yaylaci, Handan Ozek Erkuran, Murat Eyuboglu   +2 more
doaj   +1 more source

Narrative therapy, family therapy and history [PDF]

, 2009
This article was inspired by listening to the interesting plenary on the influence of narrative therapy on family therapy at the AFT annual conference in Manchester in September 2008.
Harper, David
core  

Safety and Efficacy of GLP‐1 Receptor Agonists in Adults With Epilepsy, Obesity, and Type 2 Diabetes

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Managing obesity in patients with epilepsy is complicated by the weight‐gaining properties of essential antiseizure medications (ASMs) such as valproate and pregabalin. We evaluated the safety and efficacy of initiating glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) in this population.
Hyoshin Son, Inyoung Hwang, Sang Won Lee, Yun Kim   +3 more
wiley   +1 more source

Artificial Intelligence in Systemic Sclerosis: Clinical Applications, Challenges, and Future Directions

Arthritis Care &Research, EarlyView.
Systemic sclerosis (SSc) is a rare autoimmune disease defined by immune dysregulation, vasculopathy, and progressive fibrosis of the skin and internal organs. Despite advances in care, major complications such as interstitial lung disease (ILD) and myocardial involvement remain the leading causes of morbidity and mortality.
Cristiana Sieiro Santos, José Miguel Sequí‐Sabater, Diego Benavent   +2 more
wiley   +1 more source