Results 51 to 60 of about 177,414 (289)

Phase II Proof-of-Concept Trial of the Orexin Receptor Antagonist Filorexant (MK-6096) in Patients with Major Depressive Disorder. [PDF]

, 2017
BackgroundWe evaluated the orexin receptor antagonist filorexant (MK-6096) for treatment augmentation in patients with major depressive disorder.MethodsWe conducted a 6-week, double-blind, placebo-controlled, parallel-group, Phase II, proof-of-concept ...
Ceesay, Paulette, Connor, Kathryn M, Herring, W Joseph, Hutzelmann, Jill, Krystal, Andrew D, Lines, Christopher, Michelson, David, Snavely, Duane, Thase, Michael, Trivedi, Madhukar H   +9 more
core   +1 more source

Corticosteroid therapy augments gastroduodenal permeability to sucrose

American Journal of Gastroenterology, 1998
The aim of the present study was to investigate whether corticosteroid therapy alters gastroduodenal mucosal permeability and whether permeability alteration is associated with macroscopic mucosal damage.Eight patients taking oral corticosteroid therapy (total prednisone-equivalent dose, 1.5+/-0.1 g; duration, approximately 30 days), nine patients with
Kiziltas, S, Imeryuz, N, Gurcan, T, Siva, A, Saip, S, Dumankar, A, Kalayci, C, Ulusoy, NB   +7 more
openaire   +5 more sources

Vacancy Augmented Piezo‐Sonosensitizer for Cancer Therapy

Advanced Science, 2023
AbstractSonodynamic therapy (SDT) has been widely reported as a noninvasive and high‐penetration therapy for cancer; however, the design of an efficient sonosensitizer remains an urgent need. To address this issue, molybdenum disulfide nanoflowers (MoS2 NF) as piezo‐sonosensitizers and introduced sulfur vacancies on the MoS2 NF (Sv‐MoS2 NF) to improve ...
Qingyuan Wu, Jie Zhang, Xueting Pan, Zhijun Huang, Haoyuan Zhang, Juan Guo, Yun Xue, Rui Shi, Huiyu Liu   +8 more
openaire   +3 more sources

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

Augmentation therapy in alpha-1 antitrypsin deficiency: advances and controversies

Therapeutic Advances in Respiratory Disease, 2010
Alpha-1 antitrypsin (AAT) deficiency is a hereditary condition characterized by low levels of AAT in plasma and hence diffusion into tissues. One of the most relevant characteristics of the disease is the development of panacinar emphysema due to an ...
Adriano R. Tonelli, Mark L. Brantly
doaj   +1 more source

Inter-institutional variations in oxytocin augmentation during labour in German university hospitals : a national survey [PDF]

, 2019
There are several international guidelines on oxytocin regimens for induction and augmentation of labour, but no agreement on a standardised regimen in Germany.
Daly, Deirdre, Gross, Mechthild Maria, Helbig, Sonja, Petersen, Antje, Sitter, Erika   +4 more
core   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Efficacy of Intermittent Theta‐Burst Stimulation for Prolonged Disorders of Consciousness: A Prospective, Randomized, Controlled Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Emerging evidence suggests that low‐frequency neural oscillations are dynamically regulated by consciousness levels, with the recovery of low cortical activity potentially serving as a neurophysiological substrate for conscious emergence. Targeted enhancement of these low‐frequency rhythms in patients with disorders of consciousness
Chuan Xu, Jun Hu, Qianqian Wu, Min Wu, Yamei Yu, Hangcheng Li, Jian Gao, Jingqi Li, Nai Ding, Jie Yu, Benyan Luo   +10 more
wiley   +1 more source

Evaluation of the Effect of Using Adipose Stem Cells in Bone Augmentation in Patients with Jaw Bone Atrophy: A Systematic Review and Meta-analysis [PDF]

International Journal of Scientific Research in Dental and Medical Sciences
Background and aim: Alveolar ridge bone augmentation is required for patients receiving dental implant therapy who have atrophy of the jaw bone. The latter method does not require bone harvesting, which makes it less invasive during surgery.
Hassina Shadab, Mohammad Ahmadi, Sajeya Karimi, Marzia Moez, Amena Waziri   +4 more
doaj   +1 more source