Results 31 to 40 of about 2,655,766 (243)

Frequency and Pattern of Worldwide Ocular Gene Therapy Clinical Trials up to 2022

Biomedicines, 2023
The purpose of this study is to describe worldwide gene therapy clinical trials aimed at treating ophthalmic disorders. Information regarding all worldwide clinical trials was collected through 15 different sources, including ClinicalTrials.gov.
Hossein Ameri, Niranjana Kesavamoorthy, Dara N. Bruce   +2 more
doaj   +1 more source

Image augmentation techniques for convolutional neural network [PDF]

, 2022
openUna delle più grandi sfide per le Reti Neurali Convoluzionali, soprattutto ora che vengono utilizzate ampiamente in svariati contesti, è la mancanza di training set adeguati per sessioni di training robuste e meno prone ad overfitting.
BRAVIN, RICCARDO
core  

Recommendations for the Implementation of the Self-Administration of Alpha-1 Antitrypsin

International Journal of COPD, 2023
María Torres-Durán,1 José Luis López-Campos,2,3 Myriam Calle Rubio,4 Carmen Montero-Martínez,5 Ana Priegue Carrera,6 Rosanel Amaro Rodríguez,7 Miriam Barrecheguren,8 María Ángeles Barrio Guirado,9 Francisco Javier Callejas-González,10 Francisco Casas ...
Torres-Durán M, López-Campos JL, Calle Rubio M, Montero-Martínez C, Priegue Carrera A, Amaro Rodríguez R, Barrecheguren M, Barrio Guirado MA, Callejas-González FJ, Casas-Maldonado F, Diab-Cáceres L, García-Meseguer P, Hernández-Pérez JM, Lázaro-Asegurado L, Martínez-González C, Martínez Rivera C, Michel FJ, Montoro-Ronsano JB, Sánchez R, Ortiz-Pica M, Parra I, Quintero García JP, Ruiz-Serrano-de la Espada MDR, Tortajada-Goitia B, Miravitlles M   +24 more
doaj  

Impact of heterogeneities on lateral penumbra in uniform scanning proton therapy [PDF]

, 2013
Purpose: In the treatment planning of uniform scanning proton therapy, an aperture block is designed for each beam with a margin, which typically includes the lateral penumbra measured in water (homogenous) medium.
Rana, Suresh; Department of Medical Physics, ProCure Proton Therapy Center, Oklahoma City, Singh, Hardev; Department of Medical Physics, ProCure Proton Therapy Center, Oklahoma City   +1 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Sustained high expression of human FVII following AAV8-mediated gene delivery in mice

Molecular Therapy: Methods & Clinical Development
Factor VII (FVII) deficiency is a rare bleeding disorder with a prevalence of approximately 1:300,000–500,000 individuals. We explored whether adeno-associated virus (AAV)-mediated gene therapy can achieve durable and functional expression of human FVII (
Andrea D’Amico, Bas Blits, Joëlle van den Herik, Fred de Winter, Paul H.P. Kaijen, Barbara Hobo, Alexander Henrik van Asbeck, Joost Verhaagen, David G.M. Mosmuller, Jan Voorberg   +9 more
doaj   +1 more source

The effects of weekly augmentation therapy in patients with PiZZ α1-antitrypsin deficiency

, 2012
ST Schmid,1 J Koepke,1 M Dresel,1 A Hattesohl,1 E Frenzel,2 J Perez,3 DA Lomas,4 E Miranda,5 T Greulich,1 S Noeske,1 M Wencker,6 H Teschler,6 C Vogelmeier,1 S Janciauskiene,2,* AR Koczulla1,*1Department of Internal Medicine, Division for Pulmonary ...
Janciauskiene S, Dresel M, A. Hattesohl, Rembert Koczulla, J. Koepke, Wencker M, M. Dresel, J. Perez, Noeske S, Vogelmeier C, MIRANDA BANOS, MARIA ELENA, Teschler H, Perez J, T. Greulich, S. T. Schmid, H. Teschler, E. Frenzel, M. Wencker, Koczulla AR, S. Janciauskiene, C. Vogelmeier, Koepke J, Schmid ST, D. A. Lomas, Greulich T, Lomas DA, Frenzel E, Hattesohl A, S. Noeske, Miranda E   +29 more
core   +1 more source

Data augmentation approaches for polyp segmentation [PDF]

, 2022
openImage augmentation, and in general data augmentation techniques, can greatly improve the performances of deep neural networks through the creation of artificial patterns, in fact the presence of these new patterns helps the network to generalise thus
DORIZZA, ALBERTO
core  

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Cost Comparison of Suture Anchor Modified Broström Repair and Augmentation of the Modified Broström with FiberTape Device

Foot & Ankle Orthopaedics, 2020
Category: Ankle; Sports Introduction/Purpose: Augmentation of the Broström procedure with FiberTape device has been described for the treatment of chronic ankle instability.
Emily Vannatta BS, Chris M. Stauch, Jesse King BSc, Morgan S. Kim, Laura R. Luick, Shawn M. Bifano MD, Paul J. Juliano MD, Umur Aydogan MD, Michael C. Aynardi MD   +8 more
doaj   +1 more source