Results 61 to 70 of about 9,755,150 (251)

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

Interactive space generation through play: exploring the role of simulation on the design table [PDF]

, 2005
In this paper we report on recent developments in the use of simulation as an aspect of design decision support for architecture and planning. This research is based on ARTHUR (Augmented Round Table for Architecture and Urban Planning).
F. Aish, W. Broll, J. Ohlenburg, A. Strothmann, C. Mottram, Fatah gen. Schieck, A., Attfield, S., A. Penn, Mottram, C., Ohlenburg, J., S. Attfield, Broll, W., Penn, A., A. Schieck, Aish, F.   +14 more
core  

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Safety, acceptability, and usability of an immersive gamification technology system for use in patients with behavioral and psychological symptoms of dementia (phase 1 trial)

Journal of Alzheimer's Disease Reports
Background Virtual reality (VR) is increasingly explored as a novel non-pharmacologic approach to manage Alzheimer's disease, particularly the behavioral and psychological symptoms of dementia.
Veeda Michelle M. Anlacan, Roland Dominic G. Jamora, Angelo Cedric F. Panganiban, Bryan Andrei C. Galecio, Michael L. Tee, Maria Eliza R. Aguila, Ben Anthony A. Lopez, Christian Alfredo K. Cruz, Juan Raphael M. Gonzales, Isabel Teresa O. Salido, Cherica A. Tee, Jaime D. L. Caro   +11 more
doaj   +1 more source

Augmented Reality for Art, Design and Cultural Heritage—System Design and Evaluation

EURASIP Journal on Image and Video Processing, 2009
This paper describes the design of an optical see-through head-mounted display (HMD) system for Augmented Reality (AR). Our goals were to make virtual objects “perfectly” indistinguishable from real objects, wherever the user roams, and to ...
Joachim Rotteveel, Wim van Eck, Yolande Kolstee, Jurjen Caarls, Pieter Jonker   +4 more
doaj   +1 more source

A Two‐Stage Questionnaire and Actigraphy Screening for iRBD in a Multicenter Retrospective Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Isolated rapid‐eye‐movement sleep behavior disorder is a prodromal marker of synucleinopathies. However, most cases remain undiagnosed due to the insufficient predictive value of questionnaires and limited access to confirmatory video‐polysomnography. We assessed a two‐stage screening strategy combining a brief questionnaire on rapid‐
Caleb A. Massimi, Giorgio Ricciardiello Mejia, Andre Metzger, Kang Hyun Ryu, Salonee Marwaha, Eva Grzegorczyk, Li Zhou, Eliana Jacobs, Boris Gilyadov, Claudia Kunney, Liqhwa Ncube, Ankit Parekh, Emmanuel Mignot, Fanny M. Elahi, Joseph Winer, Kathleen Poston, Andreas Brink‐Kjaer, Emmanuel H. During   +17 more
wiley   +1 more source

Thalamo‐Lesional Connectivity Signatures of Bilateral Tonic–Clonic Seizures in Focal Cortical Dysplasia‐Related Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Focal cortical dysplasia (FCD) is the most common etiology of drug‐resistant epilepsy in children. Focal to bilateral tonic–clonic seizures (FBTCS) mark a high risk of drug‐resistant epilepsy and involve thalamocortical circuitry in their generation and propagation.
Hua Xie, Xiaotong Li, Venkata Sita Priyanka Illapani, Leigh N. Sepeta, Jason Schroeder, Chima O. Oluigbo, Madison M. Berl, William D. Gaillard, Nathan T. Cohen   +8 more
wiley   +1 more source

Enhancing First-Person View Task Instruction Videos with Augmented Reality Cues

, 2020
This research investigates enhancing first-person view (FPV) task instruction videos by applying Augmented Reality (AR) visualisation of spatial cues.
William Hoff, Billinghurst, M., Lee, G.A., Seungjun Ahn, Gun A. Lee, Mark Billinghurst, Ahn, S., Hoff, W.   +7 more
core   +1 more source

Perspective: the gist of public tender for service design [PDF]

, 2018
Governments around the world are increasingly formalising design as an innovative approach to renew public services. In this development, the capabilities of external service design consultancies often play an important part, which calls for new insights
Person, Oscar, Seungho Park-Lee, Oscar Person, Park-Lee, Seungho   +3 more
core   +1 more source