Results 141 to 150 of about 335 (218)
Does Adherence Modify Low‐Dose Aspirin Effects in Pregnancy? Post Hoc Analysis From a Multi‐Centre Trial
BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.ABSTRACT Objective
To evaluate if the effect of low‐dose aspirin (LDA) commenced between 6 and 13 weeks of gestational age (GA) on preterm delivery (PTD) is modified by total exposure. Design
Post hoc analysis of a randomized controlled trial. Setting
Hospitals in low‐resource settings in Africa, Asia and Latin America.Musaku Mwenechanya, Abigail Mwapule Tembo, Elwyn Chomba, Matthew K. Hoffman, Shivaprasad S. Goudar, Janet L. Moore, Mrityunjay C. Metgud, Manjunath S. Somannavar, Jean Okitawutshu, Adrien L. Lokangaka, Antoinette K. Tshefu, Carl L. Bose, Melissa S. Bauserman, Lester Figueroa, Ana Garces, Nancy F. Krebs, Saleem Jessani, Sarah Saleem, Robert L. Goldenberg, Kunal Kurhe, Prabir Das, Archana B. Patel, Patricia L. Hibberd, Paul Nyongesa, Fabian Esamai, Sherri L. Bucher, Norman Goco, Jennifer J. Hemingway‐Foday, Denise C. Babineau, Elizabeth M. McClure, Robert M. Silver, Richard J. Derman, Waldemar A. Carlo, ASPIRIN Study Group Collaborators, Emmah Achieng, Melissa Bauserman, Carl Bose, Sherri Bucher, Waldemar Carlo, Umesh S. Charantimath, Javier Chicuy, Elwyn Chomba, Prabir Das, Richard Derman, Fabian Esamai, Lester Figueroa, M. S. Ganachari, Ana Garces, Norman Goco, Robert Goldenberg, Shivaprasad Goudar, Jennifer Hemingway‐Foday, Patricia Hibberd, Matthew Hoffman, Narayan V. Honnungar, Saleem Jessani, Avinash Kavi, Bhalachandra S. Kodkany, Marion Koso‐Thomas, Nancy Krebs, S. Yogeshkumar, Kunal Kurhe, Edward Liechty, Adrien Lokangaka, Emily MacGuire, Ashalata A. Mallapur, Elizabeth McCure, Mrityunjay C. Metgud, Menachem Miodovnik, Janet Moore, Abigail Mwapule, Musaku Mwenechanya, Farnaz Naqvi, Seemab Naqvi, Robert Nathan, Tracy Nolen, Elizabeth McClure, Paul Nyongesa, Jean Okitawutshu, Suchita Parepalli, Archana Patel, Umesh Y. Ramadurg, Sarah Saleem, Robert Silver, Manjunath S. Somannavar, Zahid Soomro, Antoinette Tshefu, Sunil S. Vernekar, Dennis Wallace, Farnaz Zehra +89 morewiley +1 more sourceOngoing Evolution of Middle East Respiratory Syndrome Coronavirus, Saudi Arabia, 2023-2024. [PDF]
Emerg Infect DisHassan AM, Mühlemann B, Al-Subhi TL, Rodon J, El-Kafrawy SA, Memish Z, Melchert J, Bleicker T, Mauno T, Perlman S, Zumla A, Jones TC, Müller MA, Corman VM, Drosten C, Azhar EI. +15 moreeuropepmc +1 more sourceType I and II Interferons Drive Abacavir Hypersensitivity via Treg Suppression and T‐Cell Enhancement in Immunocompetent HLA‐Transgenic Mice
Allergy, EarlyView.Upregulated HLA‐B*57:01 expression in Tg/KO mice amplifies abacavir‐specific CD8+ T‐cell activation, driven by enhanced antigen presentation. Abacavir treatment induces robust pDC expansion and IFN‐α production, which selectively suppresses memory Treg populations.SuJin Hwang, Telly Sepahpour, Stephanie Kortchak, Kirthiram Krishnaveni Sivakumar, Spyros Karaiskos, Ngoc Pham, Yura Jang, Montserrat Puig, Michael Norcross +8 morewiley +1 more sourceNavigating Oral Food Challenges in Clinical Trials to Keep the Science Moving Forward
Allergy, EarlyView.ABSTRACT
The oral food challenge (OFC) has long been the reference standard for food allergy diagnosis, as well as to confirm natural development of oral tolerance. The utilization of OFCs has significantly broadened from its role in defining disease to defining participant eligibility, individual allergen reactivity thresholds and treatment outcomes ...Edwin H. Kim, J. Andrew Bird, Helen A. Brough, David M. Fleischer, Stacie M. Jones, Ildiko Kun, Wayne Shreffler, Claire Van Eenwyk, Brian P. Vickery, Julie Wang, Alexandra F. Santos +10 morewiley +1 more sourceHumoral immune escape by current SARS-CoV-2 variants BA.2.86 and JN.1, December 2023. [PDF]
Euro SurveillJeworowski LM, Mühlemann B, Walper F, Schmidt ML, Jansen J, Krumbholz A, Simon-Lorière E, Jones TC, Corman VM, Drosten C. +9 moreeuropepmc +1 more sourceIron Physiology and Its Impact on Atopic Diseases: An EAACI Taskforce Report
Allergy, EarlyView.ABSTRACT
Iron is essential for oxygen transport, energy metabolism, and immune regulation. Yet iron deficiency is the most common micronutrient disorder across all age groups, affecting nearly one quarter of the global population. Iron deficiency triggers nutritional immunity, a host defense mechanism that withholds and redistributes iron, contributing Franziska Roth‐Walter, Ioana Agache, Beatriz Cabanillas, Roberto Berni Canani, Pasquale Comberiati, Holger Garn, Cristina Gomez‐Casado, Karin Hufnagl, Ekaterina Khaleva, Gregorio P. Milani, Daniel Munblit, Nikolaos Douladiris, Liam O'Mahony, Frank Redegeld, Carmen Riggioni, Peter K. Smith, Betty van Esch, Emilia Vassilopoulou, Carina Venter, Diego G. Peroni +19 morewiley +1 more sourceThe origins of patchy aurora at Jupiter. [PDF]
Nat CommunDaly A, Li W, Ma Q, Shen XC, Hue V, Clark G, Greathouse TK, Gladstone GR, Mauk BH, Kurth WS, Hospodarsky GB, Allegrini F, Bolton SJ. +12 moreeuropepmc +1 more sourceMolecular Characterization of Non‐Specific Esophagitis Reveals a Distinct Non‐Eosinophilic Phenotype With Fibrotic Traits
Allergy, EarlyView.This study comprehensively characterizes non‐specific esophagitis and elucidates eosinophil‐independent fibrosis mechanisms. NSE appears to be a distinct fibrotic phenotype of the esophagus, without any considerable overlap with GERD and other chronic inflammatory disorders such as EoE or lymphocytic esophagitis.Marc Pfefferle, Darko Stojkov, Dagmar Simon, Emilie Gueguen, Marcin Wawrzyniak, Margaret H. Collins, Mirna Chehade, Evan S. Dellon, Glenn T. Furuta, Ikuo Hirano, Nirmala Gonsalves, Fouad J. Moawad, Luc Biedermann, Alain M. Schoepfer, Alex Straumann, Hans‐Uwe Simon, Thomas Greuter +16 morewiley +1 more sourceStarspots as the origin of ultrafast drifting radio bursts from an active M dwarf. [PDF]
Sci AdvZhang J, Tian H, Bellotti S, Cang T, Callingham JR, Vedantham HK, Chen B, Yu S, Zarka P, Louis CK, Jiang P, Lu H, Gao Y, Sun J, Gan H, Li H, Sun C, Lei Z, Huang M. +18 moreeuropepmc +1 more source
