Results 31 to 40 of about 438 (257)

Spherical Skin Model: Stratified Co‐Culture of Fibroblasts and Keratinocytes on Spherical Beads Toward Compound Screening

open access: yesAdvanced Healthcare Materials, EarlyView.
Models of the human skin must combine the relevant biological contents and suitable biomaterials with the correct spatial organization. Performing compound screening on such in vitro models also requires fast and reproducible production methods of the models.
Elisa Lenzi   +7 more
wiley   +1 more source

TEMPO at Night

open access: yesEarth and Space Science
The NASA Tropospheric Emissions: Monitoring of Pollution (TEMPO) instrument is hosted on a geostationary commercial communications satellite. TEMPO is an imaging spectrometer with primary mission to measure trace‐gas concentrations from the observed ...
James L. Carr   +14 more
doaj   +1 more source

Making 3D movies of Northern Lights

open access: yesJournal of Space Weather and Space Climate, 2017
We describe the steps necessary to create three-dimensional (3D) movies of Northern Lights or Aurorae Borealis out of real-time images taken with two distant high-resolution fish-eye cameras.
Hivon Eric   +2 more
doaj   +1 more source

Ribosome Homeostasis Regulated by SETD2 Preserves Intestinal Epithelial Barrier

open access: yesAdvanced Science, EarlyView.
SETD2 ablation causes dysregulation and recruitment defects of ribosome biogenesis factors, resulting in translational disorders of barrier maintenance genes, thereby compromising the intestinal barrier. These findings unveil a previously unappreciated role of ribosome biogenesis and translational regulation in preserving the intestinal epithelial ...
Hanyu Rao   +11 more
wiley   +1 more source

Solar Flare Activity, 1937–2024: Introducing the New Hemispheric Solar Flare Index (hSFI) in the Context of 2024's Major Solar Storm Events

open access: yesSpace Weather
A new daily composite of the solar flare index (SFI) and the hemispherically‐resolved versions (hSFI) are presented for 1937 to 2024. The data set confirms that the northern hemisphere (NH) dominated solar flare activity during Solar Cycles 17 to 21, but
V. M. Velasco Herrera   +14 more
doaj   +1 more source

Fibrates Inhibit PLTP‐induced M2 Macrophage Infiltration and Increase the Sensitivity of Hepatocellular Carcinoma to ICIs

open access: yesAdvanced Science, EarlyView.
Phospholipid transfer protein(PLTP) plays a critical role in forming a complex with kinase A (AURKA) and P65. This interaction facilitates phosphorylation of P65 at Ser536, leading to the activation of the NF‐κB signaling pathway. Ultimately, this leads to the upregulation of downstream cytokines, including IL‐6, IL‐8, and CSF‐1, which promotes M2 ...
Xinyue Liang   +14 more
wiley   +1 more source

ITGB1 Regulates Triple‐Negative Breast Cancer Development by Modulating the Tumor Microenvironment

open access: yesAdvanced Science, EarlyView.
ABSTRACT Tumorigenesis and metastasis are frequently attributed to the intricate interplay between cancer cells and the tumor microenvironment (TME). Comprehending the mechanisms and key regulators of cancer‐immune crosstalk in the TME is imperative for developing efficacious immunotherapy.
Nuozi Song   +12 more
wiley   +1 more source

KDM4A Erases the H3R17me2a Mark, Facilitating Chromosome Condensation

open access: yesAdvanced Science, EarlyView.
This study reveals a reversible histone modification switch governing chromosome condensation during mitosis. PKCα‐activated KDM4A removes H3R17me2a, permitting Suv39h1‐driven H3K9me3 deposition. This epigenetic transition recruits the chromosomal passenger complex and triggers Aurora B‐dependent H3S10 phosphorylation, coordinating chromatin remodeling
Yena Cho   +6 more
wiley   +1 more source

Species of Dendrostoma (Erythrogloeaceae, Diaporthales) associated with chestnut and oak canker diseases in China [PDF]

open access: yesMycoKeys, 2019
Dendrostoma was recently proposed in Erythrogloeaceae (Diaporthales, Sordariomycetes), with all known members recorded as being plant pathogenic on economically important tree hosts.
Ning Jiang   +3 more
doaj   +3 more sources

Spatio‐Temporal Proteomic Landscape Reveals Early Warning Signals of Esophageal Squamous Cell Carcinoma Progression

open access: yesAdvanced Science, EarlyView.
This study constructs a proteomic atlas of esophageal squamous cell carcinoma (ESCC) progression using esophageal biopsy samples. It identifies moderate dysplasia as the critical turning stage and a seven‐protein panel for early detection. Functionally, GBP6 loss promotes ESCC progression via cell cycle and epithelial‐mesenchymal transition (EMT ...
Xumiao Li   +12 more
wiley   +1 more source

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