Advanced Science, Volume 9, Issue 20, July 15, 2022., 2022 Mammalian cells can synthesize nanoparticles from ions from gold salts. Gold salt drugs have been clinically applied for nearly a century, with evidence of nanoparticle formation within those patients. However, the mainstream use of these gold drugs considerably predates popular study of gold particles.
Aaron S. Schwartz‐Duval +1 more
wiley +1 more source
Medicinal Research Reviews, Volume 42, Issue 3, Page 1111-1146, May 2022., 2022 Abstract Auranofin is an oral gold(I) compound, initially developed for the treatment of rheumatoid arthritis. Currently, Auranofin is under investigation for oncological application within a drug repurposing plan due to the relevant antineoplastic activity observed both in vitro and in vivo tumor models.
Tania Gamberi +5 more
wiley +1 more source
Mitochondrial Thioredoxin System as a Modulator of Cyclophilin D Redox State [PDF]
, 2016 The mitochondrial thioredoxin system (NADPH, thioredoxin reductase, thioredoxin) is a major redox regulator. Here we have investigated the redox correlation between this system and the mitochondrial enzyme cyclophilin D.
Bindoli, Alberto +7 more
core +1 more source
Mechanistic insights into gold organometallic compounds and their biomedical application [Correction] [PDF]
, 2017 The application of gold in medicine can be traced back several thousand years and Au(i) compounds have been used in the treatment of rheumatoid arthritis since the last century.
Casini, Angela, Jürgens, Sophie
core +3 more sources
Club Cell Heme Oxygenase‐1 Deletion: Effects in Hyperoxia‐Exposed Adult Mice
Oxidative Medicine and Cellular Longevity, Volume 2020, Issue 1, 2020., 2020 Thioredoxin reductase‐1 (TXNRD1) inhibition activates nuclear factor (erythroid‐derived 2)‐like 2 (Nrf2) responses and prevents acute lung injury (ALI). Heme oxygenase‐1 (HO‐1) induction following TXNRD1 inhibition is Nrf2‐dependent in airway epithelial (club) cells in vitro. The influence of club cell HO‐1 on lung development and lung injury responses
Katelyn Dunigan-Russell +12 more
wiley +1 more source
Paradoxical roles of antioxidant enzymes:Basic mechanisms and health implications [PDF]
, 2015 Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are generated from aerobic metabolism, as a result of accidental electron leakage as well as regulated enzymatic processes.
Amit R. Reddi +38 more
core +1 more source
Decreased lipolysis and enhanced glycerol and glucose utilization by adipose tissue prior to development of obesity in monosodium glutamate (MSG) treated-rats [PDF]
, 2001 OBJECTIVE: To determine the metabolic alterations that lead to the neonatal administration of monosodium glutamate (MSG), which results in arrested growth and obesity.ANIMALS and DESIGN: Wistar rats were injected 5 times, every other day, with 4 g of MSG/
Dolnikoff, Miriam +4 more
core +2 more sources
Developing non-animal methods for thyroid toxicity testing – Validation of a novel in vitro assay investigating Deiodinase I inhibition [PDF]
, 2023 The human body can be targeted by many man-made and natural-occurring chemicals, potentially leading to adverse effects. This includes the endocrine system, essentially consisting of the EATS modalities (estrogen, androgen, thyroid, and steroidogenesis).
Weber, Andreas Georg
core +1 more source
X-ray screening identifies active site and allosteric inhibitors of SARS-CoV-2 main protease [PDF]
, 2021 The coronavirus disease (COVID-19) caused by SARS-CoV-2 is creating tremendous human suffering. To date, no effective drug is available to directly treat the disease.
Alves França, Bruno +101 more
core +5 more sources
Thioredoxin 1 modulates apoptosis induced by bioactive compounds in prostate cancer cells [PDF]
, 2017 Accumulating evidence suggests that natural bioactive compounds, alone or in combination with traditional chemotherapeutic agents, could be used as potential therapies to fight cancer. In this study, we employed four natural bioactive compounds (curcumin,
Coppo, L. +7 more
core +3 more sources