Results 21 to 30 of about 633 (125)
Role of Nrf2 and Its Activators in Respiratory Diseases
Oxidative Medicine and Cellular Longevity, Volume 2019, Issue 1, 2019., 2019 Transcription factor nuclear factor erythroid 2‐related factor 2 (Nrf2) is a major regulator of antioxidant response element‐ (ARE‐) driven cytoprotective protein expression. The activation of Nrf2 signaling plays an essential role in preventing cells and tissues from injury induced by oxidative stress.
Qinmei Liu +3 more
wiley +1 more source
Oxidative Medicine and Cellular Longevity, Volume 2019, Issue 1, 2019., 2019 Background. Aurothioglucose‐ (ATG‐) mediated inhibition of thioredoxin reductase‐1 (TXNRD1) improves alveolarization in experimental murine bronchopulmonary dysplasia (BPD). Glutathione (GSH) mediates susceptibility to neonatal and adult oxidative lung injury. We have previously shown that ATG attenuates hyperoxic lung injury and enhances glutathione‐ (
Stephanie B. Wall +7 more
wiley +1 more source
Oxidative Medicine and Cellular Longevity, Volume 2016, Issue 1, 2016., 2016 Over the last decade, a diverse spectrum of vanadium compounds has arisen as anti‐inflammatory therapeutic metallodrugs targeting various diseases. Recent studies have demonstrated that select well‐defined vanadium species are involved in many immune‐driven molecular mechanisms that regulate and influence immune responses. In addition, advances in cell
Olga Tsave +8 more
wiley +1 more source
Journal of Oncology, Volume 2009, Issue 1, 2009., 2009 The hypothesis that the Akt inhibitor, perifosine (PER), combined with inhibitors of glutathione (GSH) and thioredoxin (Trx) metabolism will induce cytotoxicity via metabolic oxidative stress in human head and neck cancer (HNSCC) cells was tested. PER induced increases in glutathione disulfide (%GSSG) in FaDu, Cal‐27, and SCC‐25 HNSCCs as well as ...
Andrean L. Simons +6 more
wiley +1 more source
Applied Organometallic Chemistry, Volume 38, Issue 10, October 2024.Heterometallic ReI/AuI complexes containing imidazo[4,5‐f]‐1,10‐phenanthroline (N^N^C) as polytopic ligand were synthesised and their antiproliferative and emissive potential analysed. The gold complex bearing a thiolate sugar derivative is the most active complex.
Andrés Luengo +3 more
wiley +1 more source
Characterisation and In Vitro Cytotoxicity of Triorganophosphinegold(I) 2‐Mercaptobenzoate Complexes
Metal-Based Drugs, Volume 6, Issue 1, Page 31-40, 1999., 1999 The preparation and full NMR ( 1H, 13C and 31P) characterisation of three R3PAu (2mba) complexes, Where R = Et, Ph and Cy, and 2mba is the anion derived from 2‐mercaptobenzoic acid is reported. An interesting solvent dependence in the 1H spectra is rationalised in terms of competing intra‐ and inter‐molecular hydrogen bonding. An X‐ray analysis of the [
Dick de Vos +4 more
wiley +1 more source
Metal-Based Drugs, Volume 6, Issue 6, Page 361-368, 1999., 1999 The antitumour activities of four triorganophosphinegold(I) thiolates, R3PAu(S′R) [R = Ph, Cy, Et; SR′H = 6‐mercaptopurine and R Et; SR′H = 6‐thioguanine] against the National Cancer Institute (NCI) panel of 60 cell lines are reported The [Cy3PAu(6‐MP)] complex proved to be the more cytotoxic of the four complexes tested.
David Crump +2 more
wiley +1 more source
Phosphinegold(I) Thiolates – Pharmacological Use and Potential
, 2003 Bioinorganic Chemistry and Applications, Volume 1, Issue 1, Page 53-67, 2003.
Edward R. T. Tiekink
wiley +1 more source
Some aspects of the diagnosis and treatment of eosinophilic granuloma in cats. [PDF]
J Vet Res, 2023 Omelchenko H +6 more
europepmc +1 more source
Delivery of the selenoprotein thioredoxin reductase 1 to mammalian cells. [PDF]
Front Mol Biosci, 2022 Wright DE +3 more
europepmc +1 more source