Results 21 to 30 of about 633 (121)

Club Cell Heme Oxygenase‐1 Deletion: Effects in Hyperoxia‐Exposed Adult Mice

Oxidative Medicine and Cellular Longevity, Volume 2020, Issue 1, 2020., 2020
Thioredoxin reductase‐1 (TXNRD1) inhibition activates nuclear factor (erythroid‐derived 2)‐like 2 (Nrf2) responses and prevents acute lung injury (ALI). Heme oxygenase‐1 (HO‐1) induction following TXNRD1 inhibition is Nrf2‐dependent in airway epithelial (club) cells in vitro. The influence of club cell HO‐1 on lung development and lung injury responses
Katelyn Dunigan-Russell, Mary Silverberg, Vivian Y. Lin, Rui Li, Stephanie B. Wall, Qian Li, Teodora Nicola, John Gotham, David R. Crowe, Peter F. Vitiello, Anupam Agarwal, Trent E. Tipple, Eric E. Kelley   +12 more
wiley   +1 more source

Role of Nrf2 and Its Activators in Respiratory Diseases

Oxidative Medicine and Cellular Longevity, Volume 2019, Issue 1, 2019., 2019
Transcription factor nuclear factor erythroid 2‐related factor 2 (Nrf2) is a major regulator of antioxidant response element‐ (ARE‐) driven cytoprotective protein expression. The activation of Nrf2 signaling plays an essential role in preventing cells and tissues from injury induced by oxidative stress.
Qinmei Liu, Yun Gao, Xinxin Ci, Luciano Saso   +3 more
wiley   +1 more source

Thioredoxin Reductase‐1 Inhibition Augments Endogenous Glutathione‐Dependent Antioxidant Responses in Experimental Bronchopulmonary Dysplasia

Oxidative Medicine and Cellular Longevity, Volume 2019, Issue 1, 2019., 2019
Background. Aurothioglucose‐ (ATG‐) mediated inhibition of thioredoxin reductase‐1 (TXNRD1) improves alveolarization in experimental murine bronchopulmonary dysplasia (BPD). Glutathione (GSH) mediates susceptibility to neonatal and adult oxidative lung injury. We have previously shown that ATG attenuates hyperoxic lung injury and enhances glutathione‐ (
Stephanie B. Wall, Rachael Wood, Katelyn Dunigan, Qian Li, Rui Li, Lynette K. Rogers, Trent E. Tipple, Demetrios Kouretas   +7 more
wiley   +1 more source

Role of Vanadium in Cellular and Molecular Immunology: Association with Immune‐Related Inflammation and Pharmacotoxicology Mechanisms

Oxidative Medicine and Cellular Longevity, Volume 2016, Issue 1, 2016., 2016
Over the last decade, a diverse spectrum of vanadium compounds has arisen as anti‐inflammatory therapeutic metallodrugs targeting various diseases. Recent studies have demonstrated that select well‐defined vanadium species are involved in many immune‐driven molecular mechanisms that regulate and influence immune responses. In addition, advances in cell
Olga Tsave, Savvas Petanidis, Efrosini Kioseoglou, Maria P. Yavropoulou, John G. Yovos, Doxakis Anestakis, Androniki Tsepa, Athanasios Salifoglou, Juan Llopis   +8 more
wiley   +1 more source

Inhibition of Glutathione and Thioredoxin Metabolism Enhances Sensitivity to Perifosine in Head and Neck Cancer Cells

Journal of Oncology, Volume 2009, Issue 1, 2009., 2009
The hypothesis that the Akt inhibitor, perifosine (PER), combined with inhibitors of glutathione (GSH) and thioredoxin (Trx) metabolism will induce cytotoxicity via metabolic oxidative stress in human head and neck cancer (HNSCC) cells was tested. PER induced increases in glutathione disulfide (%GSSG) in FaDu, Cal‐27, and SCC‐25 HNSCCs as well as ...
Andrean L. Simons, Arlene D. Parsons, Katherine A. Foster, Kevin P. Orcutt, Melissa A. Fath, Douglas R. Spitz, Paul Harari   +6 more
wiley   +1 more source

Synthesis and antiproliferative study of phosphorescent multimetallic Re(I)/Au(I) complexes containing fused imidazo[4,5‐f]‐1,10‐phenanthroline core

Applied Organometallic Chemistry, Volume 38, Issue 10, October 2024.
Heterometallic ReI/AuI complexes containing imidazo[4,5‐f]‐1,10‐phenanthroline (N^N^C) as polytopic ligand were synthesised and their antiproliferative and emissive potential analysed. The gold complex bearing a thiolate sugar derivative is the most active complex.
Andrés Luengo, Isabel Marzo, Vanesa Fernández‐Moreira, M. Concepción Gimeno   +3 more
wiley   +1 more source

Characterisation and In Vitro Cytotoxicity of Triorganophosphinegold(I) 2‐Mercaptobenzoate Complexes

Metal-Based Drugs, Volume 6, Issue 1, Page 31-40, 1999., 1999
The preparation and full NMR ( 1H, 13C and 31P) characterisation of three R3PAu (2mba) complexes, Where R = Et, Ph and Cy, and 2mba is the anion derived from 2‐mercaptobenzoic acid is reported. An interesting solvent dependence in the 1H spectra is rationalised in terms of competing intra‐ and inter‐molecular hydrogen bonding. An X‐ray analysis of the [
Dick de Vos, Phil Clements, Simon M. Pyke, Douglas R. Smyth, Edward R. T. Tiekink   +4 more
wiley   +1 more source

Phosphinegold(I) Thiolates – Pharmacological Use and Potential

, 2003
Bioinorganic Chemistry and Applications, Volume 1, Issue 1, Page 53-67, 2003.
Edward R. T. Tiekink
wiley   +1 more source

Production of Metallic Alloy Nanowires and Particles Templated Using Tomato Mosaic Virus (ToMV). [PDF]

Nanomaterials (Basel), 2023
Shah SN, Heddle JG, Evans DJ, Lomonossoff GP.   +3 more
europepmc   +1 more source

Autoimmune Hypoglycemia With Anti-Insulin Autoantibodies in an Eighty-One-Year-Old Woman Without Apparent Risk Factors. [PDF]

AACE Clin Case Rep, 2023
Kumar V, Gala D, Rafi I, Shah M, Marowa S, Kaul D, Lukose S, Kazeem S.   +7 more
europepmc   +1 more source